Evidence map›Paper›PMID 36108101›Full record

ArticleACS chemical neuroscience2022

Neuroprotective Effects of σ

Jing Jin, Nicolas Arbez, James J Sahn, Yan Lu, Kathryn T Linkens, Timothy R Hodges, Anthony Tang, Robyn Wiseman, Stephen F Martin, Christopher A Ross

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Highly specific σProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Highly specific σbioRxiv : the preprint server for biology · 2023
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jing JinDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States.
Nicolas ArbezDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States.
James J SahnDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Yan LuDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Kathryn T LinkensDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Timothy R HodgesDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Anthony TangDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States.
Robyn WisemanDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States.
Stephen F MartinDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-4639-0695
Christopher A RossDivision of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore Maryland, 21287, United States.
Johns Hopkins University · USThe University of Texas at Austin · US

Funding

Validation of Novel Pathogenic Post-Translational Modifications of Huntingtin, and of Modifying Enzymes as Therapeutic Targets for Huntington's DiseaseR01NS086452 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ROSS, CHRISTOPHER A · 2014 to 2023
$6.2M
Pharmacology and Molecular Sciences Training Program: Enhancing Inclusivity Through Universal Design for Learning in Graduate CoursesT32GM135083 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Caren L. Freel Meyers · 2020 to 2026
$3.3M
NIGMS NIH HHS T32 GM135083NINDS NIH HHS R01 NS086452
6 · The paper itself

Abstract

Huntington's disease (HD) is a genetic neurodegenerative disease caused by an expanded CAG repeat in the

Indexed as

Huntington DiseaseNeurodegenerative DiseasesNeuroprotective AgentsAnimalsDisease Models, AnimalHumansHuntingtin ProteinMembrane ProteinsNeuronsReceptors, NeurotransmitterReceptors, sigmaHuntingtin ProteinMembrane ProteinsNeuroprotective AgentsReceptors, NeurotransmitterReceptors, sigmaTMEM97 protein, humanHuntington’s diseaseneuronal survivalneuroprotectionnucleus condensationσ2R/TMEM97

Identifiers

PMID36108101
PMCPMC9547941
OpenAlexW4295932130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.