ArticlePLoS computational biology2022
Radical triads, not pairs, may explain effects of hypomagnetic fields on neurogenesis.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 0 citations in OpenAlex.
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- Human Responses to Magnetic and Hypomagnetic Fields: Available Evidence and Potential Risks for Deep Space Travel.Life (Basel, Switzerland) · 2025Review
- Weak Radiofrequency Field Effects on Biological Systems Mediated through the Radical Pair Mechanism.Chemical reviews · 2025Review
- Theoretical evaluation of the biological activity of hydrogen.Medical gas research · 2025Review
- Magnetosensitivity of tightly bound radical pairs in cryptochrome is enabled by the quantum Zeno effect.Nature communications · 2024Article
- Avian cryptochrome 4 binds superoxide.Computational and structural biotechnology journal · 2024Article
- Cryptochrome magnetoreception: Time course of photoactivation from non-equilibrium coarse-grained molecular dynamics.Computational and structural biotechnology journal · 2024Article
- Structural Rearrangements of Pigeon Cryptochrome 4 Undergoing a Complete Redox Cycle.The journal of physical chemistry. B · 2024Article
- A structural decryption of cryptochromes.Frontiers in chemistry · 2024Review
- Review
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2 authors at 1 institution in 1 country.
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Abstract
Adult hippocampal neurogenesis and hippocampus-dependent cognition in mice have been found to be adversely affected by hypomagnetic field exposure. The effect concurred with a reduction of reactive oxygen species in the absence of the geomagnetic field. A recent theoretical study suggests a mechanistic interpretation of this phenomenon in the framework of the Radical Pair Mechanism. According to this model, a flavin-superoxide radical pair, born in the singlet spin configuration, undergoes magnetic field-dependent spin dynamics such that the pair's recombination is enhanced as the applied magnetic field is reduced. This model has two ostensible weaknesses: a) the assumption of a singlet initial state is irreconcilable with known reaction pathways generating such radical pairs, and b) the model neglects the swift spin relaxation of free superoxide, which abolishes any magnetic sensitivity in geomagnetic/hypomagnetic fields. We here suggest that a model based on a radical triad and the assumption of a secondary radical scavenging reaction can, in principle, explain the phenomenon without unnatural assumptions, thus providing a coherent explanation of hypomagnetic field effects in biology.
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