Evidence map›Paper›PMID 36107859›Full record

ReviewPLoS neglected tropical diseases2022

Drug discovery research in Ghana, challenges, current efforts, and the way forward.

Richard Kwamla Amewu, Patrick Amoateng, Patrick Kobina Arthur, Prince Asare, Isaac Asiamah, Daniel Boamah, Isaac Darko Otchere, Cedric Dzidzor Amengor, Edmund Ekuadzi, Kelly Chibale and 6 more

Abstract readReview
In one paragraph

Review in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Richard Kwamla AmewuDepartment of Chemistry, University of Ghana, Legon-Accra, Ghana.ORCID 0000-0002-4676-436X
Patrick AmoatengDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Legon-Accra, Ghana.
Patrick Kobina ArthurDepartment of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon- Accra, Ghana.
Prince AsareDepartment of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Isaac AsiamahDepartment of Chemistry, School of Physical Sciences, University of Cape Coast, Cape Coast, Ghana.
Daniel BoamahDepartment of Microbiology, Centre for Plant Medicine, Mampong-Akuapem, Ghana.
Isaac Darko OtchereDepartment of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Cedric Dzidzor AmengorDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.
Edmund EkuadziDepartment of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Kelly ChibaleHolistic Drug Discovery and Development (H3D) Centre at the University of Cape Town (UCT), Rondebosch, South Africa.
Susan Jane FarrellWellcome Centre for Anti-Infectives Research (WCAIR), Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.
Regina Appiah-OppongDepartment of Clinical Pathology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Dorcas Osei-SafoDepartment of Chemistry, University of Ghana, Legon-Accra, Ghana.
Kevin David ReadWellcome Centre for Anti-Infectives Research (WCAIR), Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.
Ian Hugh GilbertWellcome Centre for Anti-Infectives Research (WCAIR), Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom.
Dorothy Yeboah-ManuDepartment of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.

Funding

Wellcome Trust 203134/Z/16/Z
6 · The paper itself

Abstract

We have a long-term vision to develop drug discovery research capacity within Ghana, to tackle unmet medical needs in Ghana and the wider West African region. However, there are several issues and challenges that need to be overcome to enable this vision, including training, human resource, equipment, infrastructure, procurement, and logistics. We discuss these challenges from the context of Ghana in this review. An important development is the universities and research centres within Ghana working together to address some of these challenges. Therefore, while there is a long way to go to fully accomplish our vision, there are encouraging signs.

Indexed as

Drug DiscoveryGhanaHumans

Identifiers

PMID36107859
PMCPMC9477258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.