ArticleNeuropsychology2022
Dispersion-based cognitive intra-individual variability in dementia with Lewy bodies.
Article in Neuropsychology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Associations of cognitive intraindividual variability with Alzheimer's disease risk: A systematic review.The Clinical neuropsychologist · 2026Pooled it
- Cognitive Intra-individual Variability in Cognitively Healthy APOE ε4 Carriers, Mild Cognitive Impairment, and Alzheimer's Disease: a Meta-analysis.Neuropsychology review · 2025Pooled it
- Reliability and stability of cognitive intraindividual variability indices among cognitively unimpaired older adults.The Clinical neuropsychologist · 2026Article
- Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease Progression.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive dispersion profiles and prediction of cognitive change in early-onset dementias: Results from LEADS.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Dispersion-based cognitive intra-individual variability in former American football players: Association with traumatic encephalopathy syndrome, repetitive head impacts, and biomarkers.The Clinical neuropsychologist · 2025Article
- Cognitive dispersion and its functional relevance in behavioral variant frontotemporal dementia and prodromal behavioral variant frontotemporal dementia.Neuropsychology · 2024Article
- Development and Validity of Norms for Cognitive Dispersion on the Uniform Data Set 3.0 Neuropsychological Battery.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Self-perceived cognitive fluctuations and their relationship to everyday functioning in older adults with and without HIV disease.The Clinical neuropsychologist · 2024Article
- Ecological validity of cognitive fluctuations in dementia with Lewy bodies.Journal of the International Neuropsychological Society : JINS · 2024Article
- Lower prospective memory is associated with higher neurocognitive dispersion in two samples of people with HIV: A conceptual replication study.Journal of the International Neuropsychological Society : JINS · 2023Article
- Predictors of within-individual variability in cognitive performance in schizophrenia in a South African case-control study.Acta neuropsychiatrica · 2023Article
- Linking cognitive variability and Alzheimer's disease biomarkers by neurocognitive status.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveCognitive fluctuations are characteristic of dementia with Lewy bodies (DLB) but challenging to measure. Dispersion-based intra-individual variability (IIV-d) captures neurocognitive performance fluctuations across a test battery and may be sensitive to cognitive fluctuations but has not been studied in DLB.
methodWe report on 5,976 participants that completed the uniform data set 3.0 neuropsychological battery (UDS3NB). IIV-d was calculated via the intra-individual standard deviation across 12 primary UDS3NB indicators. Separate models using mean USD3NB score and the Montreal cognitive assessment (MoCA) total score tested the reproducibility of the incremental value of IIV-d over-and-above global cognition. Binary logistic regressions tested whether IIV-d could classify individuals with and without clinician-rated cognitive fluctuations. Multinomial logistic regressions tested whether IIV-d could differentiate participants with DLB, participants with Alzheimer's disease (AD), and participants with healthy cognition (CH), as well as the incremental diagnostic utility of IIV-d over-and-above clinician-rated cognitive fluctuations.
resultsIIV-d exhibited large univariate associations with clinician-rated and non-clinician-informant reported cognitive fluctuations, which persisted when adjusting for MoCA but not the full battery mean. Of diagnostic relevance, greater IIV-d was consistently associated with DLB and AD relative to CH over-and-above global cognition and clinician-rated cognitive fluctuations. Greater IIV-d was less consistently associated with an increased probability of DLB relative to AD when controlling for global cognition.
conclusionsIIV-d accurately differentiates DLB from CH over-and-above global cognition and clinician-rated cognitive fluctuations. IIV-d may supplement a thorough clinical interview of cognitive fluctuations and serve as a standardized performance-based indicator of this transdiagnostic phenomenon. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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