Evidence map›Paper›PMID 36107485›Full record

Trial reporteLife2022

Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study.

Iago de Castro Silva, Anna Bianchi, Nilesh U Deshpande, Prateek Sharma, Siddharth Mehra, Vanessa Tonin Garrido, Shannon Jacqueline Saigh, Jonathan England, Peter Joel Hosein, Deukwoo Kwon and 2 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  12. Harnessing myeloid cells in cancer.Molecular cancer · 2025
    Review
  13. Inflammation, microbiota, and pancreatic cancer.Cancer cell international · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Iago de Castro SilvaDepartment of Surgery, University of Miami Miller School of Medicine, Miami, United States.ORCID 0000-0002-3898-6173
Anna BianchiDepartment of Surgery, University of Miami Miller School of Medicine, Miami, United States.
Nilesh U DeshpandeDepartment of Surgery, University of Miami Miller School of Medicine, Miami, United States.
Prateek SharmaDepartment of Surgery, University of Miami Miller School of Medicine, Miami, United States.
Siddharth MehraDepartment of Surgery, University of Miami Miller School of Medicine, Miami, United States.
Vanessa Tonin GarridoDepartment of Surgery, University of Miami Miller School of Medicine, Miami, United States.
Shannon Jacqueline SaighSylvester Comprehensive Cancer Center, Miami, United States.
Jonathan EnglandDepartment of Pathology, University of Miami, Miami, United States.
Peter Joel HoseinSylvester Comprehensive Cancer Center, Miami, United States.
Deukwoo KwonDepartment of Public Health Sciences, The University of Texas Health Science Center at Houston, Houston, United States.
Nipun B MerchantDepartment of Surgery, University of Miami Miller School of Medicine, Miami, United States.
Jashodeep DattaDepartment of Surgery, University of Miami Miller School of Medicine, Miami, United States.ORCID 0000-0003-2869-1571
University of Miami · USSylvester Comprehensive Cancer Center · USThe University of Texas Health Science Center at Houston · US

Funding

Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI George S. Grills · 2019 to 2026
$24.1M
Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
Stat3 Signaling in Pancreas CancerR01CA161976 · NCI · VANDERBILT UNIVERSITY · PI MERCHANT, NIPUN B. · 2012 to 2022
$3.4M
NCATS NIH HHS UL1 TR002736NCI NIH HHS P30 CA240139NCI NIH HHS R01 CA161976
6 · The paper itself

Abstract

Background: Partial/complete pathologic response following neoadjuvant chemotherapy (NAC) in pancreatic cancer (PDAC) patients undergoing pancreatectomy is associated with improved survival. We sought to determine whether neutrophil-to-lymphocyte ratio (NLR) dynamics predict pathologic response following chemotherapy in PDAC, and if manipulating NLR impacts chemosensitivity in preclinical models and uncovers potential mechanistic underpinnings underlying these effects. Methods: Pathologic response in PDAC patients (n=94) undergoing NAC and pancreatectomy (7/2015-12/2019) was dichotomized as partial/complete or poor/absent. Bootstrap-validated multivariable models assessed associations between pre-chemotherapy NLR (%neutrophils÷%lymphocytes) or NLR dynamics during chemotherapy (ΔNLR = pre-surgery-pre-chemotherapy NLR) and pathologic response, disease-free survival (DFS), and overall survival (OS). To preclinically model effects of NLR attenuation on chemosensitivity, Results: In 94 PDAC patients undergoing NAC (median:4 months), pre-chemotherapy NLR (p<0.001) and ΔNLR attenuation during NAC (p=0.002) were independently associated with partial/complete pathologic response. An NLR score = pre-chemotherapy NLR+ΔNLR correlated with DFS (p=0.006) and OS (p=0.002). Upon preclinical modeling, combining NLR-attenuating anti-Ly6G treatment with gemcitabine/paclitaxel-compared with gemcitabine/paclitaxel or anti-Ly6G alone-not only significantly reduced tumor burden and metastatic outgrowth, but also augmented tumor-infiltrating CD107a Conclusions: Therapeutic strategies to mitigate neutrophil-CAF-tumor cell IL-1β/IL-6/STAT-3 signaling during NAC may improve pathologic responses and/or survival in PDAC. Funding: Supported by KL2 career development grant by Miami CTSI under NIH Award UL1TR002736, Stanley Glaser Foundation, American College of Surgeons Franklin Martin Career Development Award, and Association for Academic Surgery Joel J. Roslyn Faculty Award (to J. Datta); NIH R01 CA161976 (to N.B. Merchant); and NCI/NIH Award P30CA240139 (to J. Datta and N.B. Merchant).

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsAnimalsCD8-Positive T-LymphocytesFibroblastsHumansInterleukin-6LymphocytesMiceMice, Inbred C57BLNeutrophilsPaclitaxelProto-Oncogene Proteins p21(ras)Receptor, Transforming Growth Factor-beta Type IIInterleukin-6PaclitaxelProto-Oncogene Proteins p21(ras)Receptor, Transforming Growth Factor-beta Type IIcancer associated fibroblastschemotherapy resistancehumanimmunologyinflammationmedicinemousemyeloid-derived suppressor cells (MDSCs)neutrophilspancreas cancersurgery

Identifiers

PMID36107485
PMCPMC9512403
OpenAlexW4295901435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.