Evidence map›Paper›PMID 36107354›Full record

ArticleApoptosis : an international journal on programmed cell death2022

TM2, a novel semi-synthetic taxoid, exerts anti-MDR activity in NSCLC by inhibiting P-gp function and stabilizing microtubule polymerization.

Lina Jia, Xiaoyun Gao, Yi Fang, Haotian Zhang, Lihui Wang, Xing Tang, Jingyu Yang, Chunfu Wu

Abstract read
PubMed Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Regulation of P-Glycoprotein during Oxidative Stress.Antioxidants (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lina JiaDepartment of Pharmacology, Shenyang Pharmaceutical University, No.103 Wenhua Road, 110016, Shenyang, Liaoning, China. frankjln@syphu.edu.cn.
Xiaoyun GaoDepartment of Pharmacology, Shenyang Pharmaceutical University, No.103 Wenhua Road, 110016, Shenyang, Liaoning, China.
Yi FangDepartment of Pharmacology, Shenyang Pharmaceutical University, No.103 Wenhua Road, 110016, Shenyang, Liaoning, China.
Haotian ZhangDepartment of Pharmacology, Shenyang Pharmaceutical University, No.103 Wenhua Road, 110016, Shenyang, Liaoning, China.
Lihui WangDepartment of Pharmacology, Shenyang Pharmaceutical University, No.103 Wenhua Road, 110016, Shenyang, Liaoning, China.
Xing TangDepartment of Pharmaceutics, Shenyang Pharmaceutical University, 110016, Shenyang, China.
Jingyu YangDepartment of Pharmacology, Shenyang Pharmaceutical University, No.103 Wenhua Road, 110016, Shenyang, Liaoning, China. yangjingyu2006@gmail.com.
Chunfu WuDepartment of Pharmacology, Shenyang Pharmaceutical University, No.103 Wenhua Road, 110016, Shenyang, Liaoning, China. wucf@syphu.edu.cn.
Shenyang Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Taxane agents are of particular interest in non-small cell lung carcinomas (NSCLC) treatment, while multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) limits their clinical efficacy. TM2, a chemically semi-synthesized taxane derivative, exerted significant anti-cancer efficacy in vitro and in vivo, especially against vincristine-resistant and adriamycin-resistant cancer cells. In this study, the anti-cancer effect of TM2 on drug-resistant NSCLC was evaluated both in vitro and in vivo, and the mechanism underlying its anti-MDR activity was further clarified. It was found that TM2 was significantly cytotoxic to cisplatin- and paclitaxel-resistant A549 (human non-small cell lung cancer) cells that overexpressing P-gp, resulting in IC

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungLung NeoplasmsApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1Bridged-Ring CompoundsCell Line, TumorDrug Resistance, MultipleDrug Resistance, NeoplasmHumansMicrotubulesPolymerizationTaxoidsAntineoplastic AgentsATP Binding Cassette Transporter, Subfamily B, Member 1Bridged-Ring CompoundstaxaneTaxoidsanti-MDR activityMicrotubule stabilizerMulti-drug resistanceNSCLCP-gp inhibitorTaxane derivative TM2

Identifiers

PMID36107354
OpenAlexW4295906028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.