Evidence map›Paper›PMID 36107316›Full record

ReviewAdvances in experimental medicine and biology2022

Physiological Convergence and Antagonism Between GR and PPARγ in Inflammation and Metabolism.

Marija Dacic, Gayathri Shibu, Inez Rogatsky

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marija DacicHospital for Special Surgery Research Institute, The David Rosenzweig Genomics Center, New York, NY, USA.
Gayathri ShibuHospital for Special Surgery Research Institute, The David Rosenzweig Genomics Center, New York, NY, USA.
Inez RogatskyHospital for Special Surgery Research Institute, The David Rosenzweig Genomics Center, New York, NY, USA. rogatskyi@hss.edu.
Hospital for Special Surgery · US

Funding

Glucocorticoid-regulated transcription networks in macrophage biologyR01DK099087 · NIDDK · HOSPITAL FOR SPECIAL SURGERY · PI INEZ ROGATSKY · 2014 to 2026
$6.0M
Post-Initiation control of transcription in inflammatory macrophagesR01AI148129 · NIAID · HOSPITAL FOR SPECIAL SURGERY · PI ROGATSKY, INEZ · 2020 to 2024
$3.0M
NIAID NIH HHS R01 AI148129NIDDK NIH HHS R01 DK099087
6 · The paper itself

Abstract

Nuclear receptors (NRs) are transcription factors that modulate gene expression in a ligand-dependent manner. The ubiquitously expressed glucocorticoid receptor (GR) and peroxisome proliferator-activated receptor gamma (PPARγ) represent steroid (type I) and non-steroid (type II) classes of NRs, respectively. The diverse transcriptional and physiological outcomes of their activation are highly tissue-specific. For example, in subsets of immune cells, such as macrophages, the signaling of GR and PPARγ converges to elicit an anti-inflammatory phenotype; in contrast, in the adipose tissue, their signaling can lead to reciprocal metabolic outcomes. This review explores the cooperative and divergent outcomes of GR and PPARγ functions in different cell types and tissues, including immune cells, adipose tissue and the liver. Understanding the coordinated control of these NR pathways should advance studies in the field and potentially pave the way for developing new therapeutic approaches to exploit the GR:PPARγ crosstalk.

Indexed as

PPAR gammaReceptors, GlucocorticoidAnti-Inflammatory AgentsHumansInflammationLigandsTranscription FactorsAnti-Inflammatory AgentsLigandsPPAR gammaReceptors, GlucocorticoidTranscription FactorsGlucocorticoid receptor (GR)Immune cellsInflammationMetabolic tissuesPeroxisome proliferator-activated receptor gamma (PPARγ)Transcription

Identifiers

PMID36107316
OpenAlexW4295899975

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.