SynthesisPsychophysiology2023
The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.
Synthesis in Psychophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
98 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Age-dependent modulations of hemispheric small-world networks in different eye states: resting-state electroencephalogram research.GeroScience · 2026Article
- Different functional connectivity gradients reflect aging and Alzheimer's disease.Nature neuroscience · 2026Article
- Association of psychosocial stress with altered functional connectivity of large-scale brain networks in aging adults.Cognitive, affective & behavioral neuroscience · 2026Article
- Longitudinal changes in control energy of brain networks in older adults at familial risk for Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Network-specific metabolic cost of functional connectivity in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Lights for aging: Can photobiomodulation restore functionality in the cerebral networks of aged individuals?Neural regeneration research · 2026Article
- Regional Brain Volume Variation Across Adulthood: A Cross-Sectional MRI Analysis of Age, Sex, and Hemispheric Asymmetry.Life (Basel, Switzerland) · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- The role of reading and writing history, education, and socioeconomic status on word and pseudoword naming in adult readers of Brazilian Portuguese.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2026Article
- Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review.Sports medicine and health science · 2026Review
- Distinct Brain Systems Support Afferent and Efferent Autonomic Activity.bioRxiv : the preprint server for biology · 2026Article
- Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury.GeroScience · 2026Article
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- Electrophysiological Changes in Resting-State EEG Following REAC BWO-G_B Neurobiological Modulation in Healthy Adults: A Spectral and Multivariate Exploratory Study.Brain sciences · 2026Article
- Effects of Age on Resting-State Cortical Networks.Human brain mapping · 2026Article
- Correspondence of large-scale functional brain network decline across aging mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Interplay Between Autophagy, Cellular Senescence, and Brain Aging: Neuroprotective Implications of Intermittent Fasting.Cellular and molecular neurobiology · 2026Review
- Sub-Regional Motor-Somatosensory Connectivity and Lifespan Plasticity in Functional Networks.Neurosciences (Riyadh, Saudi Arabia) · 2026Article
- Association between processing speed and segregation/integration of large-scale functional networks in middle-aged and older people living with HIV.BMC neurology · 2026Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The literature on large-scale resting-state functional brain networks across the adult lifespan was systematically reviewed. Studies published between 1986 and July 2021 were retrieved from PubMed. After reviewing 2938 records, 144 studies were included. Results on 11 network measures were summarized and assessed for certainty of the evidence using a modified GRADE method. The evidence provides high certainty that older adults display reduced within-network and increased between-network functional connectivity. Older adults also show lower segregation, modularity, efficiency and hub function, and decreased lateralization and a posterior to anterior shift at rest. Higher-order functional networks reliably showed age differences, whereas primary sensory and motor networks showed more variable results. The inflection point for network changes is often the third or fourth decade of life. Age effects were found with moderate certainty for within- and between-network altered patterns and speed of dynamic connectivity. Research on within-subject bold variability and connectivity using glucose uptake provides low certainty of age differences but warrants further study. Taken together, these age-related changes may contribute to the cognitive decline often seen in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.