Evidence map›Paper›PMID 36106757›Full record

ArticleChemMedChem2022

7H-Pyrrolo[2,3-d]pyrimidine-4-amines as Potential Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinases.

Tswene D Seanego, Hlamulo E Chavalala, Hendrik H Henning, Charles B de Koning, Heinrich C Hoppe, Kayode K Ojo, Amanda L Rousseau

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Tswene D SeanegoMolecular Sciences Institute School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, 2050, South Africa.ORCID 0000-0001-8871-5251
Hlamulo E ChavalalaMolecular Sciences Institute School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, 2050, South Africa.ORCID 0000-0002-8361-2234
Hendrik H HenningMolecular Sciences Institute School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, 2050, South Africa.ORCID 0000-0003-1921-1484
Charles B de KoningMolecular Sciences Institute School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, 2050, South Africa.
Heinrich C HoppeDepartment of Biochemistry and Microbiology, Rhodes University, Makhanda, 6140, South Africa.ORCID 0000-0003-4409-1955
Kayode K OjoCenter for Emerging and Re-emerging Infectious Diseases (CERID) Division of Allergy and Infectious Diseases Department of Medicine, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0002-2007-2170
Amanda L RousseauMolecular Sciences Institute School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, 2050, South Africa.ORCID 0000-0002-9339-1797
University of the Witwatersrand · ZARhodes University · ZAUniversity of Washington · US

Funding

Coformulation of bumped kinase inhibitors with Artemisinin combination therapy will stop widespread transmission of artemisinin-resistant malaria strainsR21AI123690 · NIAID · UNIVERSITY OF WASHINGTON · PI OJO, KAYODE K · 2017 to 2018
$490k
NIAID NIH HHS R21 AI123690
6 · The paper itself

Abstract

A series of pyrrolo[2,3-d]pyrimidines were designed in silico as potential bumped kinase inhibitors targeting P. falciparum calcium dependent protein kinase 4 (PfCDPK4), with the potential to inhibit PfCDPK1 based on earlier studies of the two kinases. A small series of these compounds were prepared and assessed for inhibitory activity against PfCDPK4 and PfCDPK1 in vitro. Four of the compounds displayed promising inhibitory activity against either PfCDPK4 (IC

Indexed as

AntimalarialsPlasmodium falciparumProtein Kinase InhibitorsAminesCalcium-Calmodulin-Dependent Protein KinasesProtein KinasesPyrimidinesStructure-Activity RelationshipAminesAntimalarialsCalcium-Calmodulin-Dependent Protein KinasesProtein Kinase InhibitorsProtein KinasesPyrimidinesbiological activitycalcium-dependent protein kinasesnitrogen heterocyclesPlasmodium falciparumpyrrolo[2,3-d]pyrimidine

Identifiers

PMID36106757
PMCPMC10286757
OpenAlexW4295900525

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.