Evidence map›Paper›PMID 36106744›Full record

ArticlemSystems2022

DNA Methyltransferase Regulates Nitric Oxide Homeostasis and Virulence in a Chronically Adapted Pseudomonas aeruginosa Strain.

Shuhong Han, Jihong Liu, Mianhuan Li, Yizhou Zhang, Xiangke Duan, Yingdan Zhang, Hao Chen, Zhao Cai, Liang Yang, Yang Liu

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Distinctive Lacritin Cleavage-Potentiated Bactericidal Alteration of thebioRxiv : the preprint server for biology · 2026
    Article
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  7. Article
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  10. Article
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  12. Species Delineation and Comparative Genomics within theJournal of clinical microbiology · 2023
    Review
  13. Article
  14. Comparative genomics and DNA methylation analysis ofFrontiers in cellular and infection microbiology · 2023
    Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shuhong HanMedical Research Center, Southern University of Science and Technology Hospital, Shenzhen, China.
Jihong LiuMedical Research Center, Southern University of Science and Technology Hospital, Shenzhen, China.
Mianhuan LiSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Yizhou ZhangMedical Research Center, Southern University of Science and Technology Hospital, Shenzhen, China.
Xiangke DuanSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Yingdan ZhangSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Hao ChenSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Zhao CaiSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Liang YangSchool of Medicine, Southern University of Science and Technology, Shenzhen, China.
Yang LiuMedical Research Center, Southern University of Science and Technology Hospital, Shenzhen, China.
Southern University of Science and Technology · CNShenzhen Third People’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opportunistic pathogens such as Pseudomonas aeruginosa adapt their genomes rapidly during chronic infections. Understanding their epigenetic regulation may provide biomarkers for diagnosis and reveal novel regulatory mechanisms. We performed single-molecule real-time sequencing (SMRT-seq) to characterize the methylome of a chronically adapted P. aeruginosa clinical strain, TBCF10839. Two

Indexed as

Epigenesis, GeneticPseudomonas aeruginosaDNADNA Modification MethylasesHomeostasisHumansMethyltransferasesNitric OxidePersistent InfectionPhylogenyVirulenceDNADNA Modification MethylasesMethyltransferasesNitric Oxidebacterium-host interactionsdenitrificationDNA methylationDNA methyltransferasePseudomonas aeruginosavirulence

Identifiers

PMID36106744
PMCPMC9600465
OpenAlexW4295898345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.