Evidence map›Paper›PMID 36106702›Full record

SynthesisResearch report (Health Effects Institute)2021

Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM

Bert Brunekreef, Maciej Strak, Jie Chen, Zorana J Andersen, Richard Atkinson, Mariska Bauwelinck, Tom Bellander, Marie-Christine Boutron, Jorgen Brandt, Iain Carey and 33 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Research report (Health Effects Institute), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 7 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 7 syntheses or guidelines pooled it, 133 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Long-Term Exposure to Low-LevelEnvironmental health perspectives · 2023
    Pooled it
  8. Article
  9. Article
  10. Article
  11. Article
  12. The triple-hit hypothesis: exploring pulmonary e-cigarette, PMEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  13. Article
  14. Observational
  15. Article
  16. Review
  17. Joint effects of PMScientific reports · 2026
    Article
  18. Article
  19. Article
  20. Review

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 17 institutions in 10 countries.

Bert BrunekreefInstitute for Risk Assessment Sciences, Utrecht University, the Netherlands.
Maciej StrakInstitute for Risk Assessment Sciences, Utrecht University, the Netherlands.
Jie ChenInstitute for Risk Assessment Sciences, Utrecht University, the Netherlands.
Zorana J AndersenDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Richard AtkinsonPopulation Health Research, Institute St George's, University of London, London, UK.
Mariska BauwelinckInterface Demography-Department of Sociology, Vrije Universiteit Brussel, Brussels, Belgium.
Tom BellanderInstitute of Environmental Medicine, Karolinska Institutet, and Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.
Marie-Christine BoutronCentre for Research in Epidemiology and Population Health, INSERM, Villejuif, France.
Jorgen BrandtDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Iain CareyPopulation Health Research, Institute St George's, University of London, London, UK.
Giulia CesaroniDepartment of Epidemiology Lazio Regional Health Service, Rome, Italy.
Francesco ForastiereDepartment of Epidemiology Lazio Regional Health Service, Rome, Italy.
Daniela FechtMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
John GulliverMRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Ole HertelDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Barbara HoffmannInstitute for Occupational, Social and Environmental Medicine, University of Duesseldorf, Duesseldorf, Germany.
Kees de HooghSwiss Tropical and Public Health Institute, Basel, Switzerland.
Danny HouthuijsNational Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Ulla HvidtfeldtDanish Cancer Society Research Center, Copenhagen, Denmark.
Nicole JanssenNational Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Jeanette JorgensenDanish Cancer Society Research Center, Copenhagen, Denmark.
Klea KatsouyanniScience Policy & Epidemiology Environmental Research Group King's College London, London, UK.
Matthias KetzelDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Jochem KlompmakerNational Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Norun Hjertager KrogDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Shuo LiuDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Petter LjungmanInstitute of Environmental Medicine, Karolinska Institutet, and Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.
Amar MehtaDepartment of Public Health, University of Copenhagen, Copenhagen, Denmark.
Gabriele NagelInstitute for Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Bente OftedalDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Goran PershagenInstitute of Environmental Medicine, Karolinska Institutet, and Centre for Occupational and Environmental Medicine, Region Stockholm, Stockholm, Sweden.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Ole Raaschou-NielsenDanish Cancer Society Research Center, Copenhagen, Denmark.
Matteo RenziDepartment of Epidemiology Lazio Regional Health Service, Rome, Italy.
Sophia RodopoulouDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Evi SamoliDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Per SchwarzeDepartment of Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
Torben SigsgaardDepartment of Environmental Science, Aarhus University, Roskilde, Denmark.
Massimo StafoggiaDepartment of Epidemiology Lazio Regional Health Service, Rome, Italy.
Danielle VienneauSwiss Tropical and Public Health Institute, Basel, Switzerland.
Gudrun WeinmayrMethods and Analysis, Statistics Denmark, Copenhagen, Denmark.
Kathrin WolfInstitute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany.
Gerard HoekInstitute for Risk Assessment Sciences, Utrecht University, the Netherlands.
Aarhus University · DKNational Institute for Public Health and the Environment · NLDanish Cancer Society · DKKarolinska Institutet · SENational and Kapodistrian University of Athens · GRNorwegian Institute of Public Health · NOUtrecht University · NLHelmholtz Zentrum München · DEStatistics Denmark · DKSt George's, University of London · GBSwiss Tropical and Public Health Institute · CHUniversity of Copenhagen · DKInserm · FRKing's College London · GBMRC Centre for Environment and HealthUniversität Ulm · DEUniversity of Leicester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEpidemiological cohort studies have consistently found associations between long-term exposure to outdoor air pollution and a range of morbidity and mortality endpoints. Recent evaluations by the World Health Organization and the Global Burden of Disease study have suggested that these associations may be nonlinear and may persist at very low concentrations. Studies conducted in North America in particular have suggested that associations with mortality persisted at concentrations of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM

methodsWe focused on analyses of health effects of air pollutants at low concentrations, defined as less than current European Union (EU) Limit Values, U.S. Environmental Protection Agency (U.S. EPA), National Ambient Air Quality Standards (NAAQS), and/or World Health Organization (WHO) Air Quality Guideline values for PM

resultsIn the pooled cohort, virtually all subjects in 2010 had PM

conclusionsLong-term exposure to PM

Indexed as

Air PollutantsAsthmaCoronary DiseaseLung NeoplasmsPulmonary Disease, Chronic ObstructiveStrokeAdultAgedCanadaCopperEnvironmental ExposureHumansIncidenceNitrogen DioxideSootSulfurAir PollutantsCopperNitrogen DioxideSootSulfurZinc

Identifiers

PMID36106702
PMCPMC9476567
OpenAlexW4295905154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.