Evidence map›Paper›PMID 36106519›Full record

ArticleBrain and behavior2022

Molecular genetic associations between a prominent serotonin transporter gene polymorphism (5-HTTLPR/rs25531) and individual differences in tendencies toward autistic traits and generalized internet use disorder in China and Germany.

YingYing Zhang, Shuxia Yao, Helena Schmitt, Benjamin Becker, Keith M Kendrick, Christian Montag

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

YingYing ZhangDepartment of Molecular Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.ORCID 0000-0002-6083-0941
Shuxia YaoThe Clinical Hospital of Chengdu Brain Science Institute, Ministry of Education Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
Helena SchmittDepartment of Molecular Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.ORCID 0000-0001-6734-6928
Benjamin BeckerThe Clinical Hospital of Chengdu Brain Science Institute, Ministry of Education Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
Keith M KendrickThe Clinical Hospital of Chengdu Brain Science Institute, Ministry of Education Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
Christian MontagDepartment of Molecular Psychology, Institute of Psychology and Education, Ulm University, Ulm, Germany.ORCID 0000-0001-8112-0837
University of Electronic Science and Technology of China · CNUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe serotonin transporter polymorphism 5-HTTLPR is an extensively investigated genetic marker of autistic traits or autism spectrum disorder, and recently has also been studied in the realm of internet use disorder (IUD), yet the findings remain controversial. Therefore, the present study aimed to explore associations between 5-HTTLPR (also including SNP rs25531) and autistic traits/IUD tendencies and to assess whether the relationship between autistic traits and IUD tendencies varies by this genetic marker in participants from China and Germany.

methodsA total of 540 Chinese and 563 German subjects were genotyped for 5-HTTLPR/rs25531 and completed the Adult Autism Spectrum Quotient questionnaire and the short version of the Internet Addiction Test.

resultsCarriers of the low expressing S'S' genotype (S, L

conclusionsOur findings suggest carriers of low expressing alleles (S, L

Indexed as

Autism Spectrum DisorderAutistic DisorderAdultAllelesGenetic MarkersGenotypeGermanyHumansIndividualityInternet UseMolecular BiologyPolymorphism, GeneticSerotonin Plasma Membrane Transport ProteinsGenetic MarkersSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanautistic traitsChinaGermanyinternet use disorderserotonin transporter gene (5-HTTLPR/rs25531)

Identifiers

PMID36106519
PMCPMC9575603
OpenAlexW4295903666

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.