Evidence map›Paper›PMID 36106151›Full record

ReviewTemperature (Austin, Tex.)2022

Human cold habituation: Physiology, timeline, and modifiers.

Beau R Yurkevicius, Billie K Alba, Afton D Seeley, John W Castellani

Open access · hybridAbstract readReview
In one paragraph

Review in Temperature (Austin, Tex.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Review
  3. Provocative testing in community dwelling older adults: a path to identify physical resilience.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. We are all exposed, but some are more exposed than others.International journal of circumpolar health · 2023
    Article
  11. Review
  12. Combining hypoxia with thermal stimuli in humans: physiological responses and potential sex differences.American journal of physiology. Regulatory, integrative and comparative physiology · 2023
    Review
  13. Article
  14. Acral skin vasoreactivity and thermosensitivity to hand cooling following 5 days of intermittent whole body cold exposure.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Beau R YurkeviciusThermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA.
Billie K AlbaThermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA.
Afton D SeeleyThermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA.
John W CastellaniThermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA.ORCID https://orcid.org/0000-0002-6728-463X
U.S. Army Research Institute of Environmental Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Habituation is an adaptation seen in many organisms, defined by a reduction in the response to repeated stimuli. Evolutionarily, habituation is thought to benefit the organism by allowing conservation of metabolic resources otherwise spent on sub-lethal provocations including repeated cold exposure. Hypermetabolic and/or insulative adaptations may occur after prolonged and severe cold exposures, resulting in enhanced cold defense mechanisms such as increased thermogenesis and peripheral vasoconstriction, respectively. Habituation occurs prior to these adaptations in response to short duration mild cold exposures, and, perhaps counterintuitively, elicits a reduction in cold defense mechanisms demonstrated through higher skin temperatures, attenuated shivering, and reduced cold sensations. These habituated responses likely serve to preserve peripheral tissue temperature and conserve energy during non-life threatening cold stress. The purpose of this review is to define habituation in general terms, present evidence for the response in non-human species, and provide an up-to-date, critical examination of past studies and the potential physiological mechanisms underlying human cold habituation. Our aim is to stimulate interest in this area of study and promote further experiments to understand this physiological adaptation.

Indexed as

Adaptationcold air exposurecold shock responsecold water immersionshiveringskin temperaturethermoregulationvasoconstriction

Identifiers

PMID36106151
PMCPMC9467574
OpenAlexW3164773528

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.