ArticleFrontiers in immunology2022
Detrimental
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Clinical, Immunological, and Genetic Features in Patients with NFKB1 and NFKB2 Mutations: a Systematic Review.Journal of clinical immunology · 2024Pooled it
- A Detrimental NFKB2 Missense Variant is Associated with Hypogammaglobulinemia.Journal of clinical immunology · 2026Article
- Rare variants in genes related to inborn errors of immunity in patients with rheumatoid arthritis and secondary immunodeficiency.RMD open · 2026Article
- Review: Utility of mass spectrometry in rare disease research and diagnosis.NPJ genomic medicine · 2025Review
- Truncating NFKB1 variants cause combined NLRP3 inflammasome activation and type I interferon signaling and predispose to necrotizing fasciitis.Cell reports. Medicine · 2024Article
- Long-term environmental metal exposure is associated with hypomethylation of CpG sites in NFKB1 and other genes related to oncogenesis.Clinical epigenetics · 2023Article
- Skin manifestations of inborn errors of NF-κB.Frontiers in pediatrics · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 18 institutions in 9 countries.
Manfred FliegaufInstitute for Immunodeficiency (IFI), Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Matias KinnunenInstitute of Biotechnology, University of Helsinki, Helsinki, Finland.
Sara Posadas-CanteraInstitute for Immunodeficiency (IFI), Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Nadezhda Camacho-OrdonezInstitute for Immunodeficiency (IFI), Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Hassan AbolhassaniDepartment of Biosciences and Nutrition, NEO, Karolinska Institutet, Huddinge, Sweden.
Laia AlsinaClinical Immunology and Primary Immunodeficiencies Unit, Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Faranaz AtschekzeiRESIST - Cluster of Excellence 2155 to Hanover Medical School , Satellite Center Freiburg, Freiburg, Germany.
Delfien J BogaertDepartment of Pediatrics, Division of Pediatric Hemato-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.
Siobhan O BurnsDepartment of Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom.
Joseph A ChurchDepartment of Pediatrics, Keck School of Medicine, University of Southern California and Children's Hospital Los Angeles, Los Angeles, CA, United States.
Gregor DückersHELIOS Children's Hospital, Krefeld, Germany.
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States.
Lennart HammarströmDepartment of Biosciences and Nutrition, NEO, Karolinska Institutet, Huddinge, Sweden.
Leif Gunnar HanitschDepartment of Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Tessa KerreDepartment of Hematology, Ghent University Hospital, Ghent, Belgium.
Robin KobbeInstitute for Infection Research and Vaccine Development (IIRVD), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Svetlana O SharapovaResearch Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus.
Kathrin SiepermannHELIOS Children's Hospital, Krefeld, Germany.
Carsten SpeckmannInstitute for Immunodeficiency (IFI), Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Sophie SteinerDepartment of Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Nisha VermaDepartment of Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom.
Jolan E WalterDivision of Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Emma Westermann-ClarkDivision of Allergy and Immunology, Department of Pediatrics, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Sigune GoldackerCenter for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Klaus WarnatzCenter for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Markku VarjosaloInstitute of Biotechnology, University of Helsinki, Helsinki, Finland.
Bodo GrimbacherInstitute for Immunodeficiency (IFI), Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
University of Freiburg · DECharité - Universitätsmedizin Berlin · DEGhent University Hospital · BEHelios Klinikum Krefeld · DERoyal Free London NHS Foundation Trust · GBUniversity Medical Center Freiburg · DEUniversity of Helsinki · FIBelarusian Research Center For Pediatric Oncology and Hematology · BYGerman Center for Infection Research · DEInstitut de Recerca Sant Joan de DéuJohns Hopkins University · USKarolinska Institutet · SEMedizinische Hochschule Hannover · DENational Institute of Allergy and Infectious Diseases · USTehran University of Medical Sciences · IRUniversität Hamburg · DEUniversity of Southern California · USUniversity of South Florida · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most of the currently known heterozygous pathogenic
Indexed as
Mutation, MissenseNF-kappa BDNAHEK293 CellsHumansNF-kappa B p50 SubunitPromoter Regions, GeneticProto-Oncogene Proteins c-relDNANF-kappa BNF-kappa B p50 SubunitNFKB1 protein, humanProto-Oncogene Proteins c-relcommon variable immunodeficiency (CVID)inborn errors of immunity (IEI)NF-kappaB signaling pathwayNFKB1primary immunodeficiency
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.