ArticleBeilstein journal of nanotechnology2022
Gelatin nanoparticles with tunable mechanical properties: effect of crosslinking time and loading.
Article in Beilstein journal of nanotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Green Fabrication of Copper and Zinc Nanoflowers Using Rheum tataricum L. and Evaluation of their Antioxidant, Enzyme-Inhibitory, Antimicrobial, and Anticancer Properties.Cell biochemistry and biophysics · 2026Article
- Effect of Genipin Crosslinking on the Cellular Delivery of Gelatin Nanocarriers Using Curcumin as a Payload.International journal of biomaterials · 2026Article
- The Role of Nanoparticle Elasticity on Biological Hydrogel Penetration.Pharmaceutics · 2025Review
- Morphological Characteristics of Biopolymer Thin Films Swollen-Rich in Solvent Vapors.Biomimetics (Basel, Switzerland) · 2024Article
- Enhancing Effector Jurkat Cell Activity and Increasing Cytotoxicity against A549 Cells Using Nivolumab as an Anti-PD-1 Agent Loaded on Gelatin Nanoparticles.Gels (Basel, Switzerland) · 2024Article
- Development of an Artificial Soft Solid Gel Using Gelatin Material for High-Quality Ultrasound Diagnosis.Diagnostics (Basel, Switzerland) · 2024Article
- Recent Strategies for Cancer Therapy: Polymer Nanoparticles Carrying Medicinally Important Phytochemicals and Their Cellular Targets.Pharmaceutics · 2023Review
- The Effect of Elasticity of Gelatin Nanoparticles on the Interaction with Macrophages.Pharmaceutics · 2023Article
- Elasticity, an often-overseen parameter in the development of nanoscale drug delivery systems.Beilstein journal of nanotechnology · 2023Article
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6 authors.
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Abstract
Tuning the elastic properties of nanoparticles intended to be used in drug delivery is of great interest. To this end, different potential formulations are developed since the particle elasticity is affecting the in vitro and in vivo performance of the nanoparticles. Here we present a method to determine the elasticity of single gelatin nanoparticles (GNPs). Furthermore, we introduce the possibility of tuning the elastic properties of gelatin nanoparticles during their preparation through crosslinking time. Young's moduli from 5.48 to 14.26 MPa have been obtained. Additionally, the possibility to measure the elasticity of single nanoparticles revealed the influence of loading a macromolecular model drug (FITC-dextran) on the mechanical properties, which decreased with raising amounts of loaded drug. Loaded particles were significantly softer, with Young's moduli between 1.06 and 5.79 MPa for the same crosslinking time, than the blank GNPs. In contrast to this, lysozyme as a crosslinkable macromolecule did not influence the mechanical properties. A good in vitro cell compatibility was found investigating blank GNPs and FITC-dextran-loaded GNPs in viability assays with the cancer cell line A549 and the human primary cell-derived hAELVi cell line.
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