Evidence map›Paper›PMID 36105479›Full record

ReviewOxidative medicine and cellular longevity2022

Natural Compounds for SIRT1-Mediated Oxidative Stress and Neuroinflammation in Stroke: A Potential Therapeutic Target in the Future.

Chaoyou Fang, Houshi Xu, Ling Yuan, Zhengyang Zhu, Xiaoyu Wang, Yibo Liu, Anke Zhang, Anwen Shao, Meiqing Lou

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Article
  8. Article
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  12. Review
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  14. The critical role of Sirt1 in ischemic stroke.Frontiers in pharmacology · 2025
    Review
  15. Review
  16. NAD-Driven Sirtuin Activation byInternational journal of molecular sciences · 2024
    Article
  17. Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chaoyou FangDepartment of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Houshi XuDepartment of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ling YuanSchool of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Zhengyang ZhuDepartment of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xiaoyu WangDepartment of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, China.
Yibo LiuDepartment of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, China.
Anke ZhangDepartment of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, China.ORCID https://orcid.org/0000-0002-0007-7724
Anwen ShaoDepartment of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, China.ORCID https://orcid.org/0000-0001-9986-6290
Meiqing LouDepartment of Neurosurgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0001-6427-5503
Shanghai Jiao Tong University · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is a fatal cerebral vascular disease with a high mortality rate and substantial economic and social costs. ROS production and neuroinflammation have been implicated in both hemorrhagic and ischemic stroke and have the most critical effects on subsequent brain injury. SIRT1, a member of the sirtuin family, plays a crucial role in modulating a wide range of physiological processes, including apoptosis, DNA repair, inflammatory response, and oxidative stress. Targeting SIRT1 to reduce ROS and neuroinflammation might represent an emerging therapeutic target for stroke. Therefore, we conducted the present review to summarize the mechanisms of SIRT1-mediated oxidative stress and neuroinflammation in stroke. In addition, we provide a comprehensive introduction to the effect of compounds and natural drugs on SIRT1 signaling related to oxidative stress and neuroinflammation in stroke. We believe that our work will be helpful to further understand the critical role of the SIRT1 signaling pathway and will provide novel therapeutic potential for stroke treatment.

Indexed as

Sirtuin 1StrokeHumansNeuroinflammatory DiseasesOxidative StressReactive Oxygen SpeciesReactive Oxygen SpeciesSIRT1 protein, humanSirtuin 1

Identifiers

PMID36105479
PMCPMC9467755
OpenAlexW4295897949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.