ArticleJournal of inflammation research2022
Relationship Between Monocyte-to-Lymphocyte Ratio as Well as Other Leukocyte-Derived Ratios and Carotid Plaques in Patients with Coronary Heart Disease: A RCSCD-TCM Study.
Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 17 citations in OpenAlex.
- ADAMDEC-1 promotes atherosclerosis progression by interacting with ACTN4 and modulating the PTEN-PI3K/AKT signaling axis.Molecular and cellular biochemistry · 2026Article
- Circulating biomarkers of carotid plaque vulnerability: current evidence, emerging markers, and barriers to clinical implementation.Biomarker research · 2026Review
- Interpretable machine learning analysis of routine blood biomarkers and derived indicators for predicting coronary heart disease in patients with carotid stenosis.BMC cardiovascular disorders · 2026Article
- CABIT: a novel biomarkers-integrated inflammatory risk tool for ischemic heart disease developed in the USA and prospectively validated in China.Journal of translational medicine · 2026Article
- Association between systemic inflammation indices and carotid plaques in acute coronary syndrome.Frontiers in cardiovascular medicine · 2026Article
- Association of platelet-lymphocyte ratio, neutrophil-lymphocyte ratio, and monocyte-lymphocyte ratio with coronary heart disease prevalence in asthma patients: a cross-sectional analysis of NHANES 1999-2018.Journal of thoracic disease · 2025Article
- Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study.Frontiers in cardiovascular medicine · 2025Article
- Association Between Systemic Immune-Inflammatory Indices and Severity of Coronary Artery Lesions in Patients With Coronary Artery Disease in Different Glucose Metabolic States.Journal of inflammation research · 2025Article
- Association between systemic inflammation response index trajectories and carotid atherosclerosis progression.Frontiers in endocrinology · 2025Article
- Monocyte-to-lymphocyte ratio as a predictor of left ventricular aneurysm in acute STEMI patients.Frontiers in endocrinology · 2025Article
- Construction of Immune-Related circRNA-miRNA-mRNA Network and Identification of circRNAs as Biomarkers in Coronary Atherosclerotic Heart Disease.Current issues in molecular biology · 2024Article
- The Monocyte-to-Lymphocyte Ratio Was Associated With Intraplaque Neovascularization of the Carotid Artery on AngioPLUS.Brain and behavior · 2024Article
- Biomarkers of systemic inflammation are associated with disease severity and metabolic syndrome in patients with hidradenitis suppurativa.JAAD international · 2024Article
- Prognostic significance of inflammation in patients with coronary artery disease at low residual inflammatory risk.iScience · 2023Article
- Association of systemic immune-inflammation index with diabetic kidney disease in patients with type 2 diabetes: a cross-sectional study in Chinese population.Frontiers in endocrinology · 2023Article
- The predictive values of monocyte-lymphocyte ratio in postoperative acute kidney injury and prognosis of patients with Stanford type A aortic dissection.Frontiers in immunology · 2023Article
- Dietary Inflammatory Index and Its Association with the Prevalence of Coronary Heart Disease among 45,306 US Adults.Nutrients · 2022Article
- [Correlation between the systemic immuneZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study explored the relationship between monocyte-to-lymphocyte ratio (MLR) as well as other leukocyte-derived ratios and carotid plaques in patients with coronary heart disease (CHD). Patients and Methods: A total of 12,093 patients with CHD were selected as research participants. Leukocyte-derived ratios assessed in this study included neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), MLR, platelet-to-lymphocyte ratio (PLR), white blood cell-to-mean platelet volume ratio (WMR), lymphocyte×neutrophil/10 Results: Among the 12,093 participants, 71.7% had carotid plaques. After adjusting for confounding factors, MLR, NLR, dNLR, PLR, SII, SIRI, and WMR were found to be associated with carotid plaque formation. Among them, MLR had the strongest association with the incidence of carotid plaques (odd ratio[OR]:1.889; 95% confidence interval[CI]:1.406-2.539) and hyperechoic plaques (OR:2.024; 95% CI:1.481-2.767). When MLR was viewed as a categorical variable, the risk of carotid plaque formation in Q4 was 1.4 times higher than that in Q1. The relationship between MLR and carotid plaques in females (OR:2.250; 95% CI:1.458-3.473) was stronger than that in males (OR: 1.638; 95% CI:1.102--2.436). The relationship between MLR and carotid plaques in patients younger than 65 years (OR:3.597; 95% CI:2.379-5.439) was stronger than that in those older than 65 years (OR:1.577; 95% CI:1.046-2.378). Conclusion: Leukocyte-derived ratios were related to the incidence, number, and echo characteristics of carotid plaques. In particular, MLR, an inflammatory biomarker that encompasses innate and adaptive immunity, may be of great value in revealing the incidence and echo characteristics of plaques.
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