Evidence map›Paper›PMID 36105312›Full record

ArticleAsian journal of pharmaceutical sciences2022

Design, preparation and pharmacodynamics of ICG-Fe(Ⅲ) based HCPT nanocrystals against cancer.

Qiongzhe Ren, Xuefeng Tang, Yi Lu, Qing Li, Zhiqian Liao, Shinan Jiang, Haoli Zhang, Zhigang Xu, Lei Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiongzhe RenCollege of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Xuefeng TangDepartment of Pathology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 401120, China.
Yi LuSchool of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, China.
Qing LiCollege of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Zhiqian LiaoCollege of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Shinan JiangCollege of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Haoli ZhangState Key Laboratory of Applied Organic Chemistry (SKLAOC), College of Chemistry and Chemical Engineering, Key Laboratory of Special Function Materials and Structure Design (MOE), Lanzhou University, Lanzhou 730000, China.
Zhigang XuSchool of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices, Southwest University, Chongqing 400715, China.
Lei LuoCollege of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of nanocrystal technology to manufacture drug delivery systems intended to enhance therapeutic efficacy has attracted the attention of the pharmaceutical industry. However, the clinical application of nanocrystal drugs for injection is restricted by Ostwald ripening and the large-scale use of stabilizers such as polysorbate and lecithin, which have potential toxicity risks including hemolysis and allergies. Here, we designed an amorphous nanocrystal drug complex (IHNC), which is stabilizer-free and composed of indocyanine green (ICG) framework loading with a chemotherapeutic agent of 10-hydroxycamptothecin (HCPT). Considering the possibility of industrial manufacturing, IHNC was simply prepared with the assistance of ferric ion (III)

Indexed as

Combination therapyDrug deliveryNanocrystalStabilizer-freeStimuli-responsive

Identifiers

PMID36105312
PMCPMC9459076

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.