ArticleFrontiers in integrative neuroscience2022
Energy supply per neuron is constrained by capillary density in the mouse brain.
Article in Frontiers in integrative neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- A Proposed Novel Neurovascular Mechanism for Brain Network Dysfunction After Traumatic Injury.Annals of biomedical engineering · 2026Article
- Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortex.Nature communications · 2026Article
- Integrating retinal and brain imaging biomarkers for diagnosis of parkinson's disease: findings from a time-lagged cross-sectional persian cohort study.Scientific reports · 2026Article
- Comparative Analysis of Regional Blood-Brain Barrier Permeability in Humans and Rodents: An Evolutionary Perspective.Research square · 2026Article
- Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High-intensity interval exercise affects neurogenesis and angiogenesis differently in diabetic and non-diabetic mice.Frontiers in neuroscience · 2026Article
- Cellular Composition of the Brain of a Northern Minke Whale.The Journal of comparative neurology · 2025Article
- Aging disrupts blood-brain and blood-spinal cord barrier homeostasis, but does not increase paracellular permeability.GeroScience · 2025Article
- A novel memristive neuron model and its energy characteristics.Cognitive neurodynamics · 2024Article
- Molecular and environmental contributors to neurological complications in sickle cell disease.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Could theropod dinosaurs have evolved to a human level of intelligence?The Journal of comparative neurology · 2023Review
- Why Does It Shine?-A Prognostic Analysis about Predisposing Factors for Blood-Brain Barrier Damage after Revascularisation of Cerebral Large-Vessel Occlusion.Journal of cardiovascular development and disease · 2023Article
- More than meets the eye: The role of microglia in healthy and diseased retina.Frontiers in immunology · 2022Review
- From a Demand-Based to a Supply-Limited Framework of Brain Metabolism.Frontiers in integrative neuroscience · 2022Article
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2 authors.
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Abstract
Neuronal densities vary enormously across sites within a brain. Does the density of the capillary bed vary accompanying the presumably larger energy requirement of sites with more neurons, or with larger neurons, or is energy supply constrained by a mostly homogeneous capillary bed? Here we find evidence for the latter, with a capillary bed that represents typically between 0.7 and 1.5% of the volume of the parenchyma across various sites in the mouse brain, whereas neuronal densities vary by at least 100-fold. As a result, the ratio of capillary cells per neuron decreases uniformly with increasing neuronal density and therefore with smaller average neuronal size across sites. Thus, given the relatively constant capillary density compared to neuronal density in the brain, blood and energy availability per neuron is presumably dependent on how many neurons compete for the limited supply provided by a mostly homogeneous capillary bed. Additionally, we find that local capillary density is not correlated with local synapse densities, although there is a small but significant correlation between lower neuronal density (and therefore larger neuronal size) and more synapses per neuron within the restricted range of 6,500-9,500 across cortical sites. Further, local variations in the glial/neuron ratio are not correlated with local variations in the number of synapses per neuron or local synaptic densities. These findings suggest that it is not that larger neurons, neurons with more synapses, or even sites with more synapses
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