Evidence map›Paper›PMID 36105254›Full record

ArticleDisease markers2022

Protein Tyrosine Phosphatase Receptor Type R (PTPRR) Reduces AChR Clustering by Dephosphorylating MuSK.

Yanxun Chen, Maohao Guan, Fengqiang Yu, Zhongshan Yang, Weiqiang Yi, Xuan Huang, Ruiqin Qiu, Fancai Lai

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yanxun ChenDepartment of Thoracic Surgery, Quangang General Hospital, The First Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China.ORCID https://orcid.org/0000-0002-4311-1785
Maohao GuanDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.ORCID https://orcid.org/0000-0002-9716-5877
Fengqiang YuDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.ORCID https://orcid.org/0000-0002-5073-2854
Zhongshan YangDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.ORCID https://orcid.org/0000-0001-8872-4027
Weiqiang YiDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.ORCID https://orcid.org/0000-0003-3418-3610
Xuan HuangDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.ORCID https://orcid.org/0000-0003-0283-1791
Ruiqin QiuDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.ORCID https://orcid.org/0000-0002-6295-5967
Fancai LaiDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.ORCID https://orcid.org/0000-0001-7108-4406
Fujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromuscular junction (NMJ) formation and maintenance depend on the proper localization and concentration of various molecules at synaptic contact sites. Acetylcholine receptor (AChR) clustering on the postsynaptic membrane is a cardinal event in NMJ formation. Muscle-specific tyrosine kinase (MuSK), which functions depending on its phosphorylation, plays an essential role in AChR clustering. In the present study, we used plasmid-based biochemical screening and determined that protein tyrosine phosphatase receptor type R (PTPRR) is responsible for dephosphorylating MuSK on tyrosine residue 754. Furthermore, we showed that PTPRR significantly reduced MuSK-dependent AChR clustering in C2C12 myotubes. Collectively, these data illustrate a negative regulation function of PTPRR in AChR clustering.

Indexed as

AcetylcholineReceptors, CholinergicCluster AnalysisHumansProtein Tyrosine PhosphatasesReceptor-Like Protein Tyrosine Phosphatases, Class 7Receptor Protein-Tyrosine KinasesAcetylcholineMUSK protein, humanProtein Tyrosine PhosphatasesPTPRR protein, humanReceptor-Like Protein Tyrosine Phosphatases, Class 7Receptor Protein-Tyrosine KinasesReceptors, Cholinergic

Identifiers

PMID36105254
PMCPMC9467777
OpenAlexW4294969125

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.