Evidence map›Paper›PMID 36105130›Full record

ArticleInternational journal of bioprinting2022

Electrohydrodynamic Jet-Printed Ultrathin Polycaprolactone Scaffolds Mimicking Bruch's Membrane for Retinal Pigment Epithelial Tissue Engineering.

Hang Liu, Fan Wu, Renwei Chen, Yanan Chen, Kai Yao, Zengping Liu, Bhav Harshad Parikh, Linzhi Jing, Tiange Liu, Xinyi Su and 2 more

Open access · diamondAbstract read
In one paragraph

Article in International journal of bioprinting, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  8. Three-dimensional bioprinting in ophthalmic care.International journal of ophthalmology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Hang LiuDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore.
Fan WuNational University of Singapore (Suzhou) Research Institute, Suzhou, China.
Renwei ChenDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore.
Yanan ChenDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore.
Kai YaoDepartment of Mechatronic and Robotics, School of Advanced Technology, Xi'an JiaoTong-Liverpool University, Suzhou, China.
Zengping LiuDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Bhav Harshad ParikhDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Linzhi JingDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore.
Tiange LiuNational University of Singapore (Suzhou) Research Institute, Suzhou, China.
Xinyi SuDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jie SunDepartment of Mechatronic and Robotics, School of Advanced Technology, Xi'an JiaoTong-Liverpool University, Suzhou, China.
Dejian HuangDepartment of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore.
National University of Singapore · SGSuzhou Research Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is the leading cause of visual loss and affects millions of people worldwide. Dysfunction of the retinal pigment epithelium (RPE) is associated with the pathogenesis of AMD. The purpose of this work is to build and evaluate the performance of ultrathin scaffolds with an electrohydrodynamic jet (EHDJ) printing method for RPE cell culture. We printed two types of ultrathin (around 7 μm) polycaprolactone scaffolds with 20 μm and 50 μm pores, which possess mechanical properties resembling that of native human Bruch's membrane and are biodegradable. Light microscopy and cell proliferation assay showed that adult human retinal pigment epithelial (ARPE-19) cells adhered and proliferated to form a monolayer on the scaffolds. The progress of culture matured on the scaffolds was demonstrated by immunofluorescence (actin, ZO-1, and Na

Indexed as

Electrohydrodynamic jet printingPolycaprolactoneRetinal pigment epitheliumUltrathin scaffolds

Identifiers

PMID36105130
PMCPMC9468949
OpenAlexW4281997545

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.