Evidence map›Paper›PMID 36105129›Full record

ArticleInternational journal of bioprinting2022

Air-loaded Gas Vesicle Nanoparticles Promote Cell Growth in Three-dimensional Bioprinted Tissue Constructs.

Salwa Alshehri, Ram Karan, Sarah Ghalayini, Kowther Kahin, Zainab Khan, Dominik Renn, Sam Mathew, Magnus Rueping, Charlotte A E Hauser

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bioprinting, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Salwa AlshehriLaboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Ram KaranKAUST Catalysis Center, Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Sarah GhalayiniLaboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Kowther KahinLaboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Zainab KhanLaboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Dominik RennKAUST Catalysis Center, Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Sam MathewKAUST Catalysis Center, Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Magnus RuepingKAUST Catalysis Center, Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Charlotte A E HauserLaboratory for Nanomedicine, Division of Biological and Environmental Science and Engineering, King Abdullah University of Science and Technology, 23955 Thuwal, Kingdom of Saudi Arabia.
Jeddah University · SAKing Abdullah University of Science and Technology · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three-dimensional (3D) bioprinting has emerged as a promising method for the engineering of tissues and organs. Still, it faces challenges in its widespread use due to issues with the development of bioink materials and the nutrient diffusion barrier inherent to these scaffold materials. Herein, we introduce a method to promote oxygen diffusion throughout the printed constructs using genetically encoded gas vesicles derived from haloarchaea. These hollow nanostructures are composed of a protein shell that allows gases to permeate freely while excluding the water flow. After printing cells with gas vesicles of various concentrations, the cells were observed to have increased activity and proliferation. These results suggest that air-filled gas vesicles can help overcome the diffusion barrier throughout the 3D bioprinted constructs by increasing oxygen availability to cells within the center of the construct. The biodegradable nature of the gas vesicle proteins combined with our promising results encourage their potential use as oxygen-promoting materials in biological samples.

Indexed as

Gas vesiclesHalobacteriumHaloferaxThree-dimensional bioprintingTissue engineering

Identifiers

PMID36105129
PMCPMC9468848
OpenAlexW4282840081

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.