Evidence map›Paper›PMID 36105066›Full record

ArticleAmerican journal of translational research2022

Wnt5a protects motor neurons in amyotrophic lateral sclerosis by regulating the Wnt/Ca

Jinmeng Liu, Fenghua Zhou, Yanchun Chen, Yingjun Guan, Fandi Meng, Zhenhan Zhao, Xuemei Wang, Xueshuai Gao, Xin Jiang, Haoyun Zhang and 3 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Gen inhibiting the Wnt/CaScientific reports · 2025
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Jinmeng LiuLaboratory of Biochemistry and Molecular Biology, Weifang Medical University Weifang 261053, Shandong, PR China.
Fenghua ZhouDepartment of Pathology, Weifang Medical University Weifang 261053, Shandong, PR China.
Yanchun ChenDepartment of Histology and Embryology, Weifang Medical University Weifang 261053, Shandong, PR China.
Yingjun GuanDepartment of Histology and Embryology, Weifang Medical University Weifang 261053, Shandong, PR China.
Fandi MengDepartment of Histology and Embryology, Weifang Medical University Weifang 261053, Shandong, PR China.
Zhenhan ZhaoDepartment of Histology and Embryology, Weifang Medical University Weifang 261053, Shandong, PR China.
Xuemei WangDepartment of Histology and Embryology, Weifang Medical University Weifang 261053, Shandong, PR China.
Xueshuai GaoDepartment of Histology and Embryology, Weifang Medical University Weifang 261053, Shandong, PR China.
Xin JiangDepartment of Histology and Embryology, Weifang Medical University Weifang 261053, Shandong, PR China.
Haoyun ZhangNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University Weifang 261053, Shandong, PR China.
Qing WangNeurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University Weifang 261053, Shandong, PR China.
Shuanhu ZhouDepartment of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School Boston 02115, MA, USA.
Xin WangDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School Boston 02115, MA, USA.
Weifang Medical University · CNBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to detect the expression profile of downstream signaling molecules of non-canonical Wnt pathway in SOD1

methodsThe expressions of CaMKII-α, CaMKII-β and TAK1 in the spinal cord of SOD1

resultsCaMKII-α, CaMKII-β, and TAK1 were down-regulated in the spinal cord of ALS mice. Ca

conclusionsThis study demonstrates that Wnt5a protects MNs in ALS by regulating cell viability, proliferation, apoptosis, and neurite growth through the Wnt/Ca

Indexed as

ALSapoptosisneurite growthproliferationWnt5aWnt/Ca2+ signaling

Identifiers

PMID36105066
PMCPMC9452359
OpenAlexW4295903670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.