ArticleAmerican journal of translational research2022
Improvement and prognosis analysis of nimotuzumab combined with TP regimen induction chemotherapy and sequential concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- [Nasopharyngeal carcinoma in children: clinical analysis of 6 cases and literature review].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- Heterogeneous nuclear ribonucleoprotein K is a potential target for enhancing the chemosensitivity of nasopharyngeal carcinoma.Open life sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore the effect of nimotuzumab combined with Taxol + Cisplatin (TP) regimen induction chemotherapy and sequential concurrent chemoradiotherapy on the improvement of curative effect and prognosis of patients with locally advanced nasopharyngeal carcinoma.
methodA retrospective analysis was performed on 91 patients with locally advanced nasopharyngeal carcinoma who were admitted to our hospital from February 2017 to February 2019, of which 41 patients received TP induction chemotherapy were assigned to control group (CG), and the remaining 50 patients received nimotuzumab on the basis of control group were assigned to observation group (OG). Both groups of patients received cisplatin chemotherapy concurrently with intensity-modulated radiotherapy (IMRT). Comparisons were made between the two group in terms of clinical efficacy, serum markers squamous cell carcinoma-associated antigen (SCCAg), cytokeratin 19 fragment 21-1 (CYFRA21-1), adverse reactions, and 3-year survival of the patients.
resultsRemission rate of cervical lymph nodes in OG was better than that in CG (P<0.05). After treatment, SCC-Ag and CYFRA21-1 decreased significantly in both groups, while indexes in OG were markedly lower compared to CG (P<0.05). During induction therapy and concurrent chemoradiotherapy, no notable difference was observed in short-term or long-term adverse reactions between the two groups (P>0.05). And Cox regression analysis found that clinical stage and treatment were independent factors affecting the prognosis of patients with disease-free survival (PFS).
conclusionNimotuzumab combined with TP regimen induction chemotherapy and sequential concurrent chemoradiotherapy can improve the curative effect of patients with locally advanced nasopharyngeal carcinoma.
Indexed as
Identifiers
36105032PMC9452316W4295908341What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.