ArticleAmerican journal of translational research2022
The value of N-terminal pro-brain natriuretic peptide and hs-CRP in predicting acute kidney injury after acute myocardial infarction.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 2 citations in OpenAlex.
- The value of NLRP, PCT, and HBP for sepsis-associated acute kidney injury and the effect of anti-inflammatory drugs.Medicine · 2026Article
- Differentiated associations of inflammatory indices with laboratory-defined organ injury/involvement and hospitalization length in pediatric respiratory tract infections.Frontiers in pediatrics · 2026Article
- A Machine Learning-Based Prediction Model for Acute Kidney Injury in Patients With Community-Acquired Pneumonia: Multicenter Validation Study.Journal of medical Internet research · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the value of combined detection of N-terminal pro-brain natriuretic peptide (NT-pro BNP) and high-sensitivity C-reactive protein (hs-CRP) in predicting acute kidney injury (AKI) after acute myocardial infarction (AMI).
methodWe retrospectively analyzed data of 107 patients with AMI admitted to our hospital from May 2020 to May 2021. The patients were assigned into an AKI group (AKIG) (n = 27) and a non-AKI group (NAKIG) (n = 80) according to whether AKI occurred within 1 week after admission. A total of 50 healthy people who underwent physical examination at the same duration were taken as control group (CG). Clinical data, expression of hs-CPR and NT-pro BNP were detected and compared between AKIG and NAKIG. Logistic regression model was applied to analyze risk factors of AKI after AMI, and Pearson linear correlation was used to analyze the correlation of hs-CRP and NT-pro BNP in patients with both AMI and AKI. Receiver operating characteristic (ROC) curve and area under the curve (AUC) were drawn and determined, and predictive value of hs-CRP and NT-pro BNP alone as well as in combination with AKI after AMI was analyzed respectively.
resultsCompared with CG, hs-CRP and NT-pro BNP of AKIG and NAKIG were markedly increased (P<0.0001). In AKIG, the levels of uric acid, blood urea nitrogen, serum creatinine (SCr), hs-CRP, NT-pro BNP were higher compared to those in NAKIG, while the estimated glomerular filtration rate (eGFR) was evidently lower than that of NAKIG (P<0.01). Logistic regression model suggested that the use of diuretics, SCr, eGFR, hs-CRP and NT-pro BNP were the risk factors of AKI in patients with AMI (P<0.05). The level of hs-CRP was positively related with NT-pro BNP (P<0.05). ROC curve analysis indicated AUCs of hs-CRP and NT-pro BNP alone as well as in combination were all over 0.8 in predicting the occurrence of AKI after AMI.
conclusionThe increase of hs-CRP and NT-pro BNP linked closely to the occurrence of AKI after AMI, and the combined detection of the two was of high value in predicting the occurrence of AKI among patients with AMI.
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36105028PMC9452361W4295905363What OpenQuestion holds
Registered trials
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