ArticleAmerican journal of translational research2022
Etomidate affects spatial learning and memory and neuronal apoptosis of rats via MAPK/ERK pathway.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors at 2 institutions in 1 country.
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Abstract
objectiveTo observe the effect of etomidate on spatial learning and memory and neuronal apoptosis in rats of different ages.
methodsThe rats of different ages were divided into 3 age groups: juvenile (21-day old), adult (~3-months old) and elderly (~19-months old). Then, rats with similar age within a group were randomly divided into three subgroups, with 10 rats in each group. The experimental subgroups were intraperitoneally injected with etomidate (emulsion formulated,
resultsEtomidate significantly extended the escape latency and reduced the platform crossings and the swimming time at original platform of juvenile rats, indicating that the spatial learning and memory function of juvenile rats can be affected by etomidate. However, etomidate had no effect on spatial learning and memory in adult and elderly rats. There were no obvious abnormalities in number of neurons and morphology of vertebral cells in the hippocampus of all experimental subgroups when compared with those of corresponding blank control subgroups. There was no statistically significant difference in apoptosis index of the hippocampal tissue between the experimental subgroups and corresponding blank control subgroups (
conclusionEtomidate may have certain effects on spatial learning and memory in juvenile rats but not in adult and elderly rats. Etomidate affects neither the number of neurons in the CA1 area of the hippocampus nor the morphology of vertebral cells and did not cause the apoptosis of nerve cells. The mechanism of etomidate influence on the spatial learning and memory function of young rats may connect with the inhibition of MAPK/ERK pathway.
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Identifiers
36105027PMC9452320W4295897960What OpenQuestion holds
Registered trials
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