Evidence map›Paper›PMID 36104868›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Dupilumab Use Is Associated With Protection From Coronavirus Disease 2019 Mortality: A Retrospective Analysis.

Alexandra N Donlan, Indika Mallawaarachchi, Jennifer M Sasson, Robert Preissner, Johanna J Loomba, William A Petri

Open access · hybridAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Alexandra N DonlanDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Indika MallawaarachchiDepartment of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Jennifer M SassonDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Robert PreissnerScience-IT and Institute of Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Johanna J LoombaIntegrated Translational Health Research Institute of Virginia (iTHRIV), Charlottesville, Virginia, USA.
William A PetriDivision of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0002-7268-1218
University of Virginia · USHumboldt-Universität zu Berlin · DE

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Role of Type 2 Immunity in Innate Protection from C. difficileR01AI124214 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2016 to 2026
$5.4M
IGNITE KUH NRSA Training CoreTL1DK132771 · NIDDK · UNIVERSITY OF VIRGINIA · PI PORTILLA, DIDIER · 2021 to 2025
$1.9M
Integrated Virginia Research Training Centers in KUH (IGNITE KUH)U2CDK129500 · NIDDK · UNIVERSITY OF VIRGINIA · PI SHARMA, RAHUL · 2021 to 2025
$1.4M
NCATS NIH HHS UL1 TR003015NIAID NIH HHS R01 AI124214NIDDK NIH HHS TL1 DK132771NIDDK NIH HHS U2C DK129500
6 · The paper itself

Abstract

We previously found that type 2 immunity promotes coronavirus disease 2019 (COVID-19) pathogenesis in a mouse model. To test relevance to human disease, we used electronic health record databases and determined that patients on dupilumab (anti-interleukin [IL]-4R monoclonal antibody that blocks IL-13 and IL-4 signaling) at the time of COVID-19 infection had lower mortality.

Indexed as

COVID-19AnimalsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedHumansMiceRetrospective StudiesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizeddupilumabCOVID-19dupilumabinfectious diseasetype 2 immunity

Identifiers

PMID36104868
PMCPMC9494491
OpenAlexW4295902330

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.