ArticleJournal of biomedical optics2022
Modeling toolchain for realistic simulation of photoacoustic data acquisition.
Article in Journal of biomedical optics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- In-silico investigation into optimal photoacoustic probe design using a digital thyroid phantom.Journal of biomedical optics · 2027Article
- Real-time deep learning-based vascular recognition in clinical breast photoacoustic imaging.Photoacoustics · 2026Article
- Realistic Ultrasound Simulations of Healthy and Osteoarthritic Cartilage.Journal of imaging · 2026Article
- Histology-based Microstructural Tissue Phantoms for Realistic Ultrasound Simulation.Ultrasonic imaging · 2026Article
- A multi-aperture encoding scheme for increased SNR in photoacoustic Imaging.Photoacoustics · 2024Article
- Deep learning assisted classification of spectral photoacoustic imaging of carotid plaques.Photoacoustics · 2023Article
- A Comprehensive Review on Photoacoustic-Based Devices for Biomedical Applications.Sensors (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significancePhysics-based simulations of photoacoustic (PA) signals are used to validate new methods, to characterize PA setups and to generate training datasets for machine learning. However, a thoroughly validated PA simulation toolchain that can simulate realistic images is still lacking.
aimA quantitative toolchain was developed to model PA image acquisition in complex tissues, by simulating both the optical fluence and the acoustic wave propagation. APPROACH: Sampling techniques were developed to decrease artifacts in acoustic simulations. The performance of the simulations was analyzed by measuring the point spread function (PSF) and using a rotatable three-channel phantom, filled with cholesterol, a human carotid plaque sample, and porcine blood. Ex vivo human plaque samples were simulated to validate the methods in more complex tissues.
resultsThe sampling techniques could enhance the quality of the simulated PA images effectively. The resolution and intensity of the PSF in the turbid medium matched the experimental data well. Overall, the appearance, signal-to-noise ratio and speckle of the images could be simulated accurately.
conclusionsA PA toolchain was developed and validated, and the results indicate a great potential of PA simulations in more complex and heterogeneous media.
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