Evidence map›Paper›PMID 36104776›Full record

ReviewGut microbes

Novel technologies to characterize and engineer the microbiome in inflammatory bowel disease.

Alba Boix-Amorós, Hilary Monaco, Elisa Sambataro, Jose C Clemente

Open access · goldAbstract readReview
In one paragraph

Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. The Microbiome in Inflammatory Bowel Disease.Journal of clinical medicine · 2024
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alba Boix-AmorósDepartment of Genetics and Genomic Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai. New York, NY, USA.ORCID 0000-0003-2776-6500
Hilary MonacoDepartment of Genetics and Genomic Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai. New York, NY, USA.ORCID 0000-0003-2660-5000
Elisa SambataroDepartment of Biological Sciences, CUNY Hunter College, New York, NY, USA.
Jose C ClementeDepartment of Genetics and Genomic Sciences, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai. New York, NY, USA.ORCID 0000-0002-3970-9856
Icahn School of Medicine at Mount Sinai · USHunter College · US

Funding

Hippocampal Inflammation as a Pathophysiology for PsychosisR01MH110418 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MALASPINA, DOLORES · 2017 to 2021
$3.8M
Optimized identification of therapeutic bacterial strains in ulcerative colitisR01DK114038 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CLEMENTE, JOSE C · 2018 to 2020
$762k
NIDDK NIH HHS R01 DK114038NIMH NIH HHS R01 MH110418
6 · The paper itself

Abstract

We present an overview of recent experimental and computational advances in technology used to characterize the microbiome, with a focus on how these developments improve our understanding of inflammatory bowel disease (IBD). Specifically, we present studies that make use of flow cytometry and metabolomics assays to provide a functional characterization of microbial communities. We also describe computational methods for strain-level resolution, temporal series, mycobiome and virome data, co-occurrence networks, and compositional data analysis. In addition, we review novel techniques to therapeutically manipulate the microbiome in IBD. We discuss the benefits and drawbacks of these technologies to increase awareness of specific biases, and to facilitate a more rigorous interpretation of results and their potential clinical application. Finally, we present future lines of research to better characterize the relation between microbial communities and IBD pathogenesis and progression.

Indexed as

Gastrointestinal MicrobiomeInflammatory Bowel DiseasesMicrobiotaChronic DiseaseHumansTechnologyflow cytometryIBDmetabolomicsmicrobial therapeuticsmicrobiomenetworkstechnologytime series

Identifiers

PMID36104776
PMCPMC9481095
OpenAlexW4295778995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.