Evidence map›Paper›PMID 36104752›Full record

ArticleCell communication and signaling : CCS2022

Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes.

Bing Xu, Ying Wang, Sherif M F M Bahriz, Meimi Zhao, Chaoqun Zhu, Yang K Xiang

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. βNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Article
  2. Article
  3. Review
  4. Differential Downregulation of βJournal of the American Heart Association · 2024
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Bing XuVA Northern California Health Care System, Mather, CA, 95655, USA.
Ying WangDepartment of Pharmacology, University of California at Davis, Davis, CA, 95616, USA.
Sherif M F M BahrizDepartment of Pharmacology, University of California at Davis, Davis, CA, 95616, USA.
Meimi ZhaoDepartment of Pharmacology, University of California at Davis, Davis, CA, 95616, USA.
Chaoqun ZhuDepartment of Pharmacology, University of California at Davis, Davis, CA, 95616, USA.
Yang K XiangVA Northern California Health Care System, Mather, CA, 95655, USA. ykxiang@ucdavis.edu.
University of California, Davis · USShenyang Pharmaceutical University · CNVA Northern California Health Care System · US

Funding

Molecular Regulation of cardiac adrenergic signalingR01HL147263 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2019 to 2022
$1.7M
NHLBI NIH HHS R01 HL147263
6 · The paper itself

Abstract

Spatiotemporal regulation of subcellular protein kinase A (PKA) activity for precise substrate phosphorylation is essential for cellular responses to hormonal stimulation. Ryanodine receptor 2 (RyR2) and (sarco)endoplasmic reticulum calcium ATPase 2a (SERCA2a) represent two critical targets of β adrenoceptor (βAR) signaling on the sarcoplasmic reticulum membrane for cardiac excitation and contraction coupling. Using novel biosensors, we show that cardiac β

Indexed as

Calcium SignalingRyanodine Receptor Calcium Release ChannelAnimalsCyclic AMP-Dependent Protein KinasesGTP-Binding ProteinsMicePhosphorylationRabbitsRatsSarcoplasmic ReticulumSarcoplasmic Reticulum Calcium-Transporting ATPasesCyclic AMP-Dependent Protein KinasesGTP-Binding ProteinsRyanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPasesCardiac contractilityCatecholaminePhosphodiesterase (PDE)Phospholamban (PLB)Ryanodine receptor (RyR)(sarco)endoplasmic reticulum calcium ATPase 2a (SERCA2a)β adrenergic receptor (βAR)β-blockers

Identifiers

PMID36104752
PMCPMC9472443
OpenAlexW4295670209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.