Evidence map›Paper›PMID 36104716›Full record

ArticleAIDS research and therapy2022

Identification of CD8

Federico Perdomo-Celis, David Arcia-Anaya, Juan Carlos Alzate, Paula A Velilla, Francisco J Díaz, Maria Paulina Posada, María T Rugeles, Natalia A Taborda

Abstract read
In one paragraph

Article in AIDS research and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Federico Perdomo-CelisGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia.
David Arcia-AnayaCentre for Cancer Immunology, Faculty of Medicine, University Hospital Southampton, Southampton, UK.
Juan Carlos AlzateUnidad de Investigación Clínica - Corporación para Investigaciones Biológicas, Medellín, Colombia.
Paula A VelillaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia.
Francisco J DíazGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia.
Maria Paulina PosadaIPS SIES Salud, Medellín, Colombia.
María T RugelesGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia.
Natalia A TabordaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia - UdeA, Medellín, Colombia. natalia.taborda@uniremington.edu.co.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough combined antiretroviral therapy (cART) has decreased the mortality associated with HIV infection, complete immune reconstitution is not achieved despite viral suppression. Alterations of CD8

methodsWe explored the changes in the frequencies, activation/exhaustion phenotypes (HLA-DR, CD38, PD-1, and TIM-3), and function (total and HIV-specific cells expressing CD107a, perforin, granzyme B, interferon [IFN]-γ and IL-17) of CD8

resultsDespite continuous cART-induced viral suppression and recovery of CD4

conclusionsAlthough suppressive cART achieves normalization of CD4

Indexed as

HIV InfectionsCD8-Positive T-LymphocytesGranzymesHumansInterleukin-17PerforinProgrammed Cell Death 1 ReceptorT-Lymphocyte SubsetsGranzymesInterleukin-17PerforinProgrammed Cell Death 1 ReceptorAntiretroviral therapyCD8-positive T-lymphocytesHIVImmune reconstitution

Identifiers

PMID36104716
PMCPMC9476577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.