ArticleClinical oral investigations2022
Comparative chemical properties, bioactivity, and cytotoxicity of resin-modified calcium silicate-based pulp capping materials on human dental pulp stem cells.
Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical and radiographic outcomes of three calcium silicate-based cements in primary tooth pulpotomy: a randomized clinical trial.BMC oral health · 2026Trial
- Development of an experimental pulp capping material containing antibacterial and remineralizing peptide: an in vitro study.BMC oral health · 2026Article
- Comparison of five different Light-Cured Pulp Capping Materials to a Hydraulic Calcium Silicate Cement: A Long-Term Physicochemical Study.International dental journal · 2026Article
- Effect of external cervical resorptive defects restored with two bioceramic materials, short glass fiber-reinforced composite and nanohybrid composite on fracture resistance of maxillary anterior teeth: an in-vitro study.Clinical oral investigations · 2026Article
- Calcium Silicate-Based Cements for Vital Pulp Therapy: Integrated Assessment of Radiopacity, Elemental Composition, and 24-h Pulp Cell Responses.Biomimetics (Basel, Switzerland) · 2026Article
- In Vitro Evaluation of Novel Resin-Modified Calcium Silicate Cements for Minimally Invasive Vital Pulp Therapy.International dental journal · 2026Article
- Clinical and Radiographic Outcomes of Vital Pulp Therapy Using Resin-Modified Versus Conventional Calcium Silicate-Based Materials: A Systematic Review and Meta-Analysis.Journal of functional biomaterials · 2026Review
- Article
- Evaluation of thermal rise on simulated pulp tissue during light-cured direct capping in vitro: an artificial microcirculation study.BMC oral health · 2025Article
- Effect of light-cured pulp capping materials on human dental pulp cells in vitro.International endodontic journal · 2025Article
- Effect of TheraCal PT and Biodentine on inflammatory cell infiltration and hard tissue formation after pulpotomy in inflamed or healthy rat molars.Clinical oral investigations · 2025Article
- Article
- Histological Evaluation of Polyacid-Modified Composite Resin and Conventional Composite Resin Used for Primary Molars Restoration.Dentistry journal · 2024Article
- Evaluation of biocompatibility and bioactive potential of Well-Root PT by comparison with ProRoot MTA and Biodentine.Journal of dental sciences · 2024Article
- Hygroscopic bioactive light-cured composite promoting dentine bridge formation.Regenerative biomaterials · 2024Article
- Specimen Shape and Elution Time Affect the Mineralization and Differentiation Potential of Dental Pulp Stem Cells to Biodentine.Journal of functional biomaterials · 2023Article
- Comparative biological properties of resin-free and resin-based calcium silicate-based endodontic repair materials on human periodontal ligament stem cells.Clinical oral investigations · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThis study investigated the cytotoxicity, the residual monomer release, degree of conversion (DC), calcium ion (Ca MATERIALS AND
methodsThe cytotoxicity of the cured materials was evaluated on human dental pulp stem cells (hDPSCs) isolated from third molars by the water-soluble tetrazolium salt (WST-1) method. The monomer release and DC of the resin-containing materials were analyzed by high-performance liquid chromatography (HPLC) and Fourier transform infrared (FTIR), respectively. The chemical composition and Ca
resultsMTA showed significantly lower cytotoxicity than either ThLC or ThPT after 1, 3, and 7 days (p < 0.05). TEGDMA release of ThPT is significantly higher than ThLC (p < 0.05). All materials showed calcium Ca
conclusionsMTA showed low cytotoxicity and high Ca CLINICAL RELEVANCE: The cytotoxicity and residual monomer release of ThLC and ThPT may raise concerns about the viability of hDPSCs. Further investigations with the use of in vivo research models are required to validate in vitro bioactivity properties and the potential adverse biological effects of ThLC and ThPT on hDPSCs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.