ArticleEJNMMI physics2022
Comparison between a dual-time-window protocol and other simplified protocols for dynamic total-body
Article in EJNMMI physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 29 citations in OpenAlex.
- Kinetic modeling with total body PET-current status and future applications.The British journal of radiology · 2026Review
- Parametric imaging of dynamic long-axial-field-of-view PET scans: Technical challenges, statistical insights and clinical applications.Zeitschrift fur medizinische Physik · 2026Review
- The impact of scan time on dynamic [Formula: see text]-FAPI-04 total-body PET parametric imaging generated by deep learning models.EJNMMI physics · 2026Article
- Total Body PET.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Article
- Neural network-aided unsupervised input function estimation for dual-time-window PET Patlak analysis.EJNMMI physics · 2025Article
- Feasibility of Early DynamicMolecular imaging and biology · 2025Article
- Use of relative Patlak plot Ki' images as an alternative to standard Patlak plot Ki images in clinical practice.EJNMMI research · 2025Article
- Quantitative Measurement of Tau Burden in a Dual-Time-Window Dynamic PET Imaging Protocol with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- Article
- Evaluation of early chemotherapy response by combining static- and dynamic [EJNMMI research · 2025Article
- The value of dynamic FDG PET/CT in the differential diagnosis of lung cancer and predicting EGFR mutations.BMC pulmonary medicine · 2024Article
- Performance and application of the total-body PET/CT scanner: a literature review.EJNMMI research · 2024Review
- Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [European journal of nuclear medicine and molecular imaging · 2024Article
- Clinical feasibility study of early 30-minute dynamic FDG-PET scanning protocol for patients with lung lesions.EJNMMI physics · 2024Article
- The role of dynamic, static, and delayed total-body PET imaging in the detection and differential diagnosis of oncological lesions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Quantitation of dynamic total-body PET imaging: recent developments and future perspectives.European journal of nuclear medicine and molecular imaging · 2023Review
- Diagnostic Value of DynamicDiagnostics (Basel, Switzerland) · 2023Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeEfforts have been made both to avoid invasive blood sampling and to shorten the scan duration for dynamic positron emission tomography (PET) imaging. A total-body scanner, such as the uEXPLORER PET/CT, can relieve these challenges through the following features: First, the whole-body coverage allows for noninvasive input function from the aortic arteries; second, with a dramatic increase in sensitivity, image quality can still be maintained at a high level even with a shorter scan duration than usual. We implemented a dual-time-window (DTW) protocol for a dynamic total-body
methodsThe research included 28 patient scans performed on an uEXPLORER PET/CT. By discarding the corresponding data in the middle of the existing full 60-min dynamic scan, the DTW protocol was simulated. Nonlinear fitting was used to estimate the missing data in the interval. The full input function was obtained from 15 subjects using a hybrid approach with a population-based image-derived input function. Quantification was carried out in three areas: the cerebral cortex, muscle, and tumor lesion. Micro- and macro-kinetic parameters for different scan durations were estimated by assuming an irreversible two-tissue compartment model. The visual performance of parametric images and region of interest-based quantification in several parameters were evaluated. Furthermore, simplified quantification methods (DTW, Patlak, fractional uptake ratio [FUR], and standardized uptake value [SUV]) were compared for similarity to the reference net influx rate K
resultsK
conclusionsUsing the DTW protocol, the dynamic total-body FDG scan time can be reduced to 15 min while obtaining accurate K
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.