ArticleInflammation2023
Diagnostic and Prognostic Value of Deregulated Circulating Long Non-coding RNA TUG1 in Elderly Patients with Severe Pneumonia.
Article in Inflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- MIR210HG promotes the progression of pediatric pneumonia by inducing apoptosis and inflammation through downregulating miR-195-5p and upregulating FGF2.BMC pediatrics · 2026Article
- Potential role of serological biomarkers in the diagnosis and prediction of community-acquired pneumonia in elderly individuals.Frontiers in medicine · 2025Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the expression pattern of long non-coding RNA TUG1 in elderly patients with severe community-acquired pneumonia (sCAP) and evaluate its diagnostic and prognostic value for sCAP. Serum TUG1 levels were detected in 130 sCAP patients and 122 healthy volunteers via qRT-PCR method. The receiver operating characteristic (ROC) curve and k-M plot were drawn for the diagnostic and prognostic value evaluation. A diminished trend of TUG1 was detected in the serum of sCAP cases, and negatively correlated with the concentration of TNF-α, CRP, suPAR and sTREM-1. Among the 130 cases, 30 cases died from sCAP within 30 days after admission. Serum TUG1 had the diagnostic value for 30-day mortality prediction with the AUC of 0.823. In the non-survival group, more cases had old age, high CURB score and PSI score. K-M plot demonstrated that cases with low TUG1 levels showed poor survival than those carrying high TUG1 levels. Serum TUG1 was an independent risk factor for death in elderly patients with sCAP within 30 days after admission. Serum TUG1 was at low expression in sCAP patients, and it had the predictive value for the clinical prognosis of elderly sCAP patients.
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