ArticleScientific reports2022
Epidemiology, genetic diversity, and association of canine circovirus infection in dogs with respiratory disease.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Advances in Avian Diagnostic Pathology: Current Trends, Challenges and Future Directions: A Review.Veterinary medicine and science · 2026Review
- Evidence of feline chaphamaparvovirus in dogs: molecular detection, genetic recombination, and tissue localization.BMC veterinary research · 2025Article
- Genetic Diversity of Canine Circovirus Detected in Wild Carnivores in Serbia.Veterinary sciences · 2025Article
- Canine circovirus: an emerging virus of dogs and wild canids.Irish veterinary journal · 2025Review
- Investigation of truncated replication protein mutant of Canine Circovirus: synergistic interaction with Feline Panleukopenia Virus.Frontiers in veterinary science · 2025Article
- Detection of pathogens in dogs with respiratory disease during winter 2023-2024 using multiplex qPCR/RT-qPCR assays and next-generation sequencing.Frontiers in veterinary science · 2025Article
- Canine circovirus: emergence, adaptation, and challenges for animal and public health.Frontiers in veterinary science · 2025Review
- Epidemiological and evolutionary analysis of canine circovirus from 1996 to 2023.BMC veterinary research · 2024Article
- Molecular characterization of canine circovirus based on the Capsid gene in Thailand.BMC veterinary research · 2024Article
- Evolutionary dynamics of canine kobuvirus in Vietnam and Thailand reveal the evidence of viral ability to evade host immunity.Scientific reports · 2024Article
- Recombinant expression and characterization of Canine circovirus capsid protein for diagnosis.Frontiers in veterinary science · 2024Article
- Mechanisms of circovirus immunosuppression and pathogenesis with a focus on porcine circovirus 2: a review.The veterinary quarterly · 2023Review
- Detection of Selected Canine Viruses in Nigerian Free-Ranging Dogs Traded for Meat Consumption.Animals : an open access journal from MDPI · 2023Article
- Canine circovirus among dogs and cats in China: first identification in cats.Frontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although canine circovirus (CanineCV)-associated with gastroenteritis has been well documented, the virus is also detectable in the respiratory discharge of dogs with respiratory disease. In this study, an epidemiological approach was used to explore the association between the presence of CanineCV and respiratory symptoms in dogs. Respiratory swabs were collected from 76 healthy dogs and 114 dogs with respiratory illness and tested for CanineCV using conventional PCR (cPCR). Furthermore, lung tissues collected from 15 necropsied dogs showing pneumonia were tested using the real-time PCR (qPCR) and in situ hybridization (ISH) technique. A total of 8.95% (17/190) of dogs were CanineCV positive, with a significant association (p = 0.013) in dogs with respiratory signs. Four necropsied dogs were qPCR positive with the CanineCV-DNA labeling localized in tracheobronchial lymphoid cells (3/4), pulmonary parenchyma, capillary endothelia, and mononuclear cells harboring in alveoli (2/4). Full-length genome sequences of seven CanineCV strains were analyzed, indicating that the detected CanineCV genome clustered in the CanineCV-4 genotype. Genetic recombination was also evident in the replicase (Rep) gene. Although the role of CanineCV primarily affecting lung lesions could not be determined from this study, the presence of CanineCV DNA in pulmonary-associated cells indicated the potential association of the virus with canine respiratory disease; thus, linking causality must be examined in further studies.
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