ArticleBMJ open respiratory research2022
Validity of the ROX index in predicting invasive mechanical ventilation requirement in pneumonia.
Article in BMJ open respiratory research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Prediction of high-flow nasal cannula failure in critically ill patients: a narrative review.Journal of intensive care · 2026Review
- Predictors of Intensive Care Unit Outcomes in Elderly Patients with Acute Respiratory Failure: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Predictive Factors for Invasive Mechanical Ventilation in Community-acquired Pneumonia.Internal medicine (Tokyo, Japan) · 2025Article
- Comparisons of mortality predictions of mROX, CURB-65, and APACHE II in patients with severe pneumonia: A retrospective cohort study.Medicine · 2025Article
- Comparison of the Predictive Capacity of Oxygenation Parameters, Oxygenation Indices, and CURB-65 to Mortality, Mechanical Ventilation, and Vasopressor Support in Community-Acquired Pneumonia at Different Altitudes.Canadian respiratory journal · 2025Article
- Comparison of performances between risk scores for predicting mortality at 30 days in patients with community acquired pneumonia.BMC infectious diseases · 2024Article
- Performance of oxygenation indices and risk scores to predict invasive mechanical ventilation and mortality in COVID-19.BMC pulmonary medicine · 2024Article
- Optimizing the safety and efficacy of the awake venovenous extracorporeal membrane oxygenation in patients with COVID-19-related ARDS.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
18 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe ROX index (
methodsThis is a retrospective cohort study including subjects with CAP treated in the general ward, emergency service or intensive care unit of a third-level centre in Cundinamarca, Colombia, between January 2001 and February 2020. The ROX index was estimated as the ratio of oxygen saturation/fraction of inspired oxygen to respiratory rate.
resultsA total of 895 patients were included, of whom 93 (10%) required IMV. The ROX index proved to be a good predictor, presenting an area under the curve of receiver operating characteristics (AUROC) of 0.733 (95% CI 0.671 to 0.795, p<0.001) when determined by pulse oximetry and an AUROC of 0.779 (95% CI 0.699 to 0.859, p<0.001) when estimated by arterial blood gas (ABG) parameters, with an intraclass correlation of 0.894. The estimated cut-off point was 14.8; a score less than 14.8 indicates high risk of requiring IMV.
conclusionThe ROX index is a good predictor of IMV in hospitalised patients with CAP. It presents good performance when calculated through pulse oximetry and can replace the one calculated by ABG.
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