ArticleJournal of psychiatry & neuroscience : JPN
Reduced signal propagation elicited by frontal transcranial magnetic stimulation is associated with oligodendrocyte abnormalities in treatment-resistant depression.
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10 citing papers in PubMed, 16 citations in OpenAlex.
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Frontoparietal network mediates the antidepressant effects of accelerated iTBS and cTBS: TMS-EEG study.Cell reports. Medicine · 2025Article
- Validation of an electroencephalography data assimilation-based computational approach for estimating cortical excitation-inhibition balance.Communications engineering · 2025Article
- Unveiling Major Depressive Disorder Through TMS-EEG: From Traditional to Emerging Approaches.Biomedicines · 2025Review
- Repetitive Trans-spinal Magnetic Stimulation Suppresses Microglia to Engulf Synapse and Promotes Nerve Repairment via cGAS-STING Signaling Pathway after Spinal Cord Injury.International journal of biological sciences · 2025Article
- Decreased prefrontal glutamatergic function is associated with a reduced astrocyte-related gene expression in treatment-resistant depression.Translational psychiatry · 2024Article
- Neuroplasticity of the left dorsolateral prefrontal cortex in patients with treatment-resistant depression as indexed with paired associative stimulation: a TMS-EEG study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Development of Artificial Intelligence for Determining Major Depressive Disorder Based on Resting-State EEG and Single-Pulse Transcranial Magnetic Stimulation-Evoked EEG Indices.Journal of personalized medicine · 2024Article
- Neuromodulation for treatment-resistant depression: Functional network targets contributing to antidepressive outcomes.Frontiers in human neuroscience · 2023Review
- Sex Differences of the Functional Brain Activity in Treatment-Resistant Depression: A Resting-State Functional Magnetic Resonance Study.Brain sciences · 2022Article
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Authors and funding
14 authors at 6 institutions in 3 countries.
Masataka WadaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Shinichiro NakajimaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis) yoshi-tms@keio.jp shinichiro_nakajima@hotmail.com.
Shiori HondaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Mayuko TakanoFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Keita TaniguchiFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Sakiko TsugawaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Yu MimuraFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Nanao HattoriFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Shinsuke KoikeFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Reza ZomorrodiFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Daniel M BlumbergerFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Zafiris J DaskalakisFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Masaru MimuraFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis).
Yoshihiro NodaFrom the Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan (Wada, Nakajima, Honda, Takano, Taniguchi, Tsugawa, Y. Mimura, Hattori, M. Mimura, Noda); the Multimodal Imaging Group, Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ont. (Nakajima); Teijin Pharma Ltd., Tokyo, Japan (Takano); the Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, University of Tokyo, Tokyo, Japan (Koike); the Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont. (Zomorrodi, Blumberger); the Department of Psychiatry, Faculty of Health, University of California San Diego, San Diego, CA (Daskalakis) yoshi-tms@keio.jp shinichiro_nakajima@hotmail.com.
Honda (Japan) · JPCentre for Addiction and Mental Health · CAKeio University · JPThe University of Tokyo · JPUniversity of California, San Diego · USUniversity of Toronto · CA
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe efficacy of repetitive transcranial magnetic stimulation (rTMS) to the left dorsolateral prefrontal cortex (dlPFC) has been established in patients with treatment-resistant depression (TRD), suggesting that alterations in signal propagation from the left dlPFC to other brain regions may be linked to the pathophysiology of TRD. Alterations at the cellular level, including dysfunction of oligodendrocytes, may contribute to these network abnormalities. The objectives of the present study were to compare signal propagation from the left dlPFC to other neural networks in patients with TRD and healthy controls. We used TMS combined with electroencephalography to explore links between cell-specific gene expression and signal propagation in TRD using a virtual-histology approach.
methodsWe examined source-level estimated signal propagation from the left dlPFC to the 7 neural networks in 60 patients with TRD and 30 healthy controls. We also calculated correlations between the interregional profiles of altered signal propagation and gene expression for 9 neural cell types derived from the Allen Human Brain Atlas data set.
resultsSignal propagation from the left dlPFC to the salience network was reduced in the θ and α bands in patients with TRD ( LIMITATIONS: These results show only part of the pathophysiology of TRD, because stimulation was limited to the left dlPFC.
conclusionReduced signal propagation from the left dlPFC to the salience network may represent a pathophysiological endophenotype of TRD; this finding may be associated with reduced expression of oligodendrocytes.
Indexed as
Depressive Disorder, Treatment-ResistantTranscranial Magnetic StimulationDepressionHumansOligodendrogliaPrefrontal Cortex
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