Evidence map›Paper›PMID 36103880›Full record

ArticleCell reports. Medicine2022

Disentangling the cognitive, physical, and mental health sequelae of COVID-19.

Conor J Wild, Loretta Norton, David K Menon, David A Ripsman, Richard H Swartz, Adrian M Owen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  18. Brain fog as a Long-term Sequela of COVID-19.SN comprehensive clinical medicine · 2023
    Review
  19. Neurocognitive Profiles in Patients With Persisting Cognitive Symptoms Associated With COVID-19.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022
    Observational
  20. Rehabilitation Strategies for Cognitive and Neuropsychiatric Manifestations of COVID-19.Current physical medicine and rehabilitation reports · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Conor J WildWestern Institute for Neuroscience, Western University, London, ON N6A 3K7, Canada; Department of Physiology and Pharmacology, Western University, London, ON N6A 3K7, Canada. Electronic address: cwild@uwo.ca.
Loretta NortonWestern Institute for Neuroscience, Western University, London, ON N6A 3K7, Canada; Department of Psychology, King's University College, Western University, London, ON N6A 3K7, Canada.
David K MenonDivision of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge CB2 2QQ, UK.
David A RipsmanFaculty of Medicine, Department of Neurology, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Richard H SwartzDepartment of Medicine (Neurology), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Center, University of Toronto, Toronto, ON M4N 3M5, Canada.
Adrian M OwenWestern Institute for Neuroscience, Western University, London, ON N6A 3K7, Canada; Department of Physiology and Pharmacology, Western University, London, ON N6A 3K7, Canada; Department of Psychology, Western University, London, ON N6A 3K7, Canada.
Western University · CASunnybrook Health Science Centre · CAUniversity of British Columbia · CAUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As COVID-19 cases exceed hundreds of millions globally, many survivors face cognitive challenges and prolonged symptoms. However, important questions about the cognitive effects of COVID-19 remain unresolved. In this cross-sectional online study, 478 adult volunteers who self-reported a positive test for COVID-19 (mean = 30 days since most recent test) perform significantly worse than pre-pandemic norms on cognitive measures of processing speed, reasoning, verbal, and overall performance, but not short-term memory, suggesting domain-specific deficits. Cognitive differences are even observed in participants who did not require hospitalization. Factor analysis of health- and COVID-related questionnaires reveals two clusters of symptoms-one that varies mostly with physical symptoms and illness severity, and one with mental health. Cognitive performance is positively correlated with the global measure encompassing physical symptoms, but not the one that broadly describes mental health, suggesting that the subjective experience of "long COVID" relates to physical symptoms and cognitive deficits, especially executive dysfunction.

Indexed as

COVID-19Mental HealthAdultCognitionCross-Sectional StudiesHumansNeuropsychological TestscognitionCOVID-19cross-sectional online studylong COVIDmental healthphysical health

Identifiers

PMID36103880
PMCPMC9448696
OpenAlexW4294861176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.