ArticleScience advances2022
In situ diagnosis and simultaneous treatment of cardiac diseases using a single-device platform.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
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- Multi-Channel Neural Interface for Neural Recording and Neuromodulation.Small methods · 2026Review
- Autonomous Polymer Frameworks for Sustainable Tissue-Interfaced Plastic Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Connexin 40 in atrial fibrillation: pathophysiological roles and regulatory mechanisms.Annals of medicine · 2025Review
- Integrated Polymeric Sensors in Heart and Blood Vessel Monitoring: A Review.Sensors (Basel, Switzerland) · 2025Review
- Advancements in Bio-Integrated Flexible Electronics for Hemodynamic Monitoring in Cardiovascular Healthcare.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Development of Stimuli-Responsive Polymeric Nanomedicines in Hypoxic Tumors and Their Therapeutic Promise in Oral Cancer.Polymers · 2025Review
- Damage-free dry transfer method using stress engineering for high-performance flexible two- and three-dimensional electronics.Nature materials · 2024Article
- Interference haptic stimulation and consistent quantitative tactility in transparent electrotactile screen with pressure-sensitive transistors.Nature communications · 2024Article
- Implementation of an epicardial implantable MEMS sensor for continuous and real-time postoperative assessment of left ventricular activity in adult minipigs over a short- and long-term period.APL bioengineering · 2024Article
- Permanent fluidic magnets for liquid bioelectronics.Nature materials · 2024Article
- Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management.Chemical reviews · 2023Review
- Chronological adhesive cardiac patch for synchronous mechanophysiological monitoring and electrocoupling therapy.Nature communications · 2023Article
- Flexible electronics for cardiovascular healthcare monitoring.Innovation (Cambridge (Mass.)) · 2023Review
- Stretchable Surface Electrode Arrays Using an Alginate/PEDOT:PSS-Based Conductive Hydrogel for Conformal Brain Interfacing.Polymers · 2022Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in situ diagnosis of cardiac activities with simultaneous therapeutic electrical stimulation of the heart is key to preventing cardiac arrhythmia. Here, we present an unconventional single-device platform that enables in situ monitoring even in a wet condition and control of beating heart motions without interferences to the recording signal. This platform consists of the active-matrix array of pressure-sensitive transistors for detecting cardiac beatings, biocompatible, low-impedance electrodes for cardiac stimulations, and an alginate-based hydrogel adhesive for attaching this platform conformally to the epicardium. In contrast to conventional electrophysiological sensing using electrodes, the pressure-sensitive transistors measured mechanophysiological characteristics by monitoring the spatiotemporal distributions of cardiac pressures during heart beating motions. In vivo tests show mechanophysiological readings having good correlation with electrocardiography and negligible interference with the electrical artifacts caused during cardiac stimulations. This platform can therapeutically synchronize the rhythm of abnormal heartbeats through efficient pacing of cardiac arrhythmia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.