ArticleScience translational medicine2022
Poly(ADP-ribose) promotes toxicity of
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Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- BDNF insufficiency exacerbates ALS progression.Cell reports. Medicine · 2026Article
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- PAR-Driven Condensation Maintains Stalled Replication Fork Stability.bioRxiv : the preprint server for biology · 2026Article
- Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase.Nature communications · 2026Article
- Condensatopathies as a mechanistic framework for disease and integrated theranostic intervention.Theranostics · 2026Review
- NEDD8, stress granules, and amyotrophic lateral sclerosis: unveiling the therapeutic potential of the NEDP1 protease.Essays in biochemistry · 2025Review
- Primate-specific adaptation of Ku protects transcriptomic integrity by suppressing Alu-mediated alternative splicing.bioRxiv : the preprint server for biology · 2025Article
- Tipping the PARylation scale: Dysregulation of PAR signaling in Huntington and neurodegenerative diseases.Journal of Huntington's disease · 2025Review
- Transient Poly(ADP-Ribose) Triggers FUS Condensation Hysteresis via a Prion-Like Mechanism.bioRxiv : the preprint server for biology · 2025Article
- A pH-Centric Model of Nucleolar Activity and Regulation.Journal of molecular biology · 2025Review
- PARPs and ADP-ribosylation-mediated biomolecular condensates: determinants, dynamics, and disease implications.Trends in biochemical sciences · 2025Review
- Parthanatos: Mechanisms, modulation, and therapeutic prospects in neurodegenerative disease and stroke.Biochemical pharmacology · 2024Review
- A comparison study of pathological features and drug efficacy between Drosophila models of C9orf72 ALS/FTD.Molecules and cells · 2024Article
- Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions.Cell reports · 2023Article
- (Dys)functional insights into nucleic acids and RNA-binding proteins modulation of the prion protein and α-synuclein phase separation.Biophysical reviews · 2023Review
- Regulation of Biomolecular Condensates by Poly(ADP-ribose).Chemical reviews · 2023Review
- Review
- DNA Damage-Mediated Neurotoxicity in Parkinson's Disease.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 6 institutions in 3 countries.
Junli GaoDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-8207-5545
Quinlan T MewborneDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-7738-4255
Amandeep GirdharDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-0523-6683
Udit ShethDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-4360-7892
Alyssa N CoyneDepartment of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-3658-5325
Ritika PunathilDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-2501-9982
Bong Gu KangDepartment of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-0594-9509
Morgan DasovichDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-7951-9662
Austin VeireDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-9327-0103
Mariely DeJesus HernandezDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
Shuaichen LiuDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Zheng ShiDepartment of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA.ORCID 0000-0002-5214-1871
Ruxandra DafincaNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0003-0776-6431
Elise FouquerelDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-2542-2563
Kevin TalbotNuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.ORCID 0000-0001-5490-1697
Tae-In KamDepartment of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7241-4902
Yong-Jie ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-9900-4313
Dennis DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7189-7917
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-2959-129X
Marka van BlitterswijkDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-3054-7053
Lin GuoDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-2589-9513
Ted M DawsonDepartment of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-6459-0893
Valina L DawsonDepartment of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-2915-3970
Anthony K L LeungDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.ORCID 0000-0001-5569-4036
Thomas E LloydDepartment of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4756-3700
Tania F GendronDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-7335-2627
Jeffrey D RothsteinDepartment of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-2001-8470
Ke ZhangDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-4794-8355
Mayo Clinic in Florida · USJohns Hopkins University · USThomas Jefferson University · USJohn Radcliffe Hospital · GBRutgers, The State University of New Jersey · USShenzhen Bay Laboratory · CN
Funding
Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI FRYER, JOHN DAVID · 2014 to 2024
$17.6MResource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5MMurine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9MValidation of r(G4C2)exp-binding small molecules in vivo and c9FTD/ALS biomarker developmentP01NS099114 · NINDS · UNIVERSITY OF FLORIDA · PI ROTHSTEIN, JEFFREY D · 2017 to 2021
$6.5MParthanatos, AIF and PAAN-1 in Neuronal InjuryR37NS067525 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DAWSON, TED M., DAWSON, VALINA L. · 2015 to 2021
$5.3MRole of ADP-Ribosylation in Stress Granules-Equipment SupplementR01GM104135 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Anthony K L Leung · 2015 to 2026
$4.2MFrontotemporal dementia and related disorders: transcriptomic profiling, biomarker discovery, and mechanistic insightR01NS121125 · NINDS · MAYO CLINIC JACKSONVILLE · PI GENDRON, TANIA FRANCE, VAN BLITTERSWIJK, MARKA · 2021 to 2025
$3.9MNucleocytoplasmic transport and nuclear pore disruption in ALS/FTDR01NS094239 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E., ROTHSTEIN, JEFFREY D · 2016 to 2020
$3.4MOligodendroglial Dysfunction in C9orf72 ALS and FTDR01NS099320 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MORRISON, BRETT M., ROTHSTEIN, JEFFREY D · 2017 to 2021
$3.0MPoly(ADP-ribose) promotes the condensation and toxicity of C9orf72 arginine-rich dipeptide repeat proteinsR01NS117461 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Tania France Gendron, Yongjie Zhang · 2021 to 2026
$2.9MALS/FTD mutant C9orf72-induced genetic and nuclear pathology in iPS cell modelsR01NS085207 · NINDS · JOHNS HOPKINS UNIVERSITY · PI ROTHSTEIN, JEFFREY D, SATTLER, RITA · 2013 to 2017
$1.8MDynactin function in axons, synapses, and neurodegenerative diseaseR01NS082563 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LLOYD, THOMAS E. · 2013 to 2017
$1.8MMotor Neurone Disease Association TALBOT-MUTIHAC/APR15/832-791NIGMS NIH HHS R01 GM104135NIH HHS P40 OD018537NINDS NIH HHS K99 NS123242NINDS NIH HHS P01 NS084974NINDS NIH HHS P01 NS099114NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS082563NINDS NIH HHS R01 NS085207NINDS NIH HHS R01 NS094239NINDS NIH HHS R01 NS099320NINDS NIH HHS R01 NS117461NINDS NIH HHS R01 NS121125NINDS NIH HHS R37 NS067525NINDS NIH HHS RF1 NS121143NINDS NIH HHS U24 NS078736
Abstract
Arginine-rich dipeptide repeat proteins (R-DPRs), abnormal translational products of a GGGGCC hexanucleotide repeat expansion in
Indexed as
Frontotemporal DementiaArginineC9orf72 ProteinDipeptidesDNA-Binding ProteinsHumansPoly Adenosine Diphosphate RiboseArginineC9orf72 ProteinC9orf72 protein, humanDipeptidesDNA-Binding ProteinsPoly Adenosine Diphosphate Ribose
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.