ArticleInfection and immunity1987
Resistance to Paracoccidioides brasiliensis in mice is controlled by a single dominant autosomal gene.
Article in Infection and immunity, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Genetic background and immune response in paracoccidioidomycosis: A systematic review and meta-analysis of single nucleotide variants.PLoS neglected tropical diseases · 2026Pooled it
- Polymorphism in the Promoter Region of theFrontiers in immunology · 2020Trial
- Metabolic complications of psychotropic medications in psychiatric disorders: Emerging role ofWorld journal of psychiatry · 2024Review
- Review
- Hormones and the resistance of women to paracoccidioidomycosis.Clinical microbiology reviews · 2011Review
- Anti-idiotypic antibodies in patients with different clinical forms of paracoccidioidomycosis.Clinical and diagnostic laboratory immunology · 2000Article
- Morphological transition of Paracoccidioides brasiliensis conidia to yeast cells: in vivo inhibition in females.Infection and immunity · 1998Article
- Influence of the genetic pattern and sex of mice in experimental paracoccidioidomycosis.Clinical and experimental immunology · 1995Article
- Effect of macrophage blockade on the resistance of inbred mice to Paracoccidioides brasiliensis infection.Mycopathologia · 1995Article
- Pulmonary paracoccidioidomycosis in resistant and susceptible mice: relationship among progression of infection, bronchoalveolar cell activation, cellular immune response, and specific isotype patterns.Infection and immunity · 1995Article
- Pathogenicity of Saccharomyces cerevisiae in complement factor five-deficient mice.Infection and immunity · 1995Article
- Delayed-type hypersensitivity response in an isogenic murine model of paracoccidioidomycosis.Mycopathologia · 1994Article
- Experimental murine paracoccidioidomycosis: relationship among the dissemination of the infection, humoral and cellular immune responses.Clinical and experimental immunology · 1993Article
- Specific recognition pattern of IgM and IgG antibodies produced in the course of experimental paracoccidioidomycosis.Clinical and experimental immunology · 1992Article
- Studies on the relationship between paracoccidioidomycosis in ddY mice and their estrous cycle.Mycopathologia · 1991Article
- A single gene controls resistance to Japanese encephalitis virus in mice.Archives of virology · 1990Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous report it was shown that there are resistant, susceptible, and intermediate strains of mice to intraperitoneal Paracoccidioides brasiliensis infection. In the present work, we investigated the type of inheritance and the number of genes that determine resistance to paracoccidioidomycosis. Parental and hybrid mice were inoculated intraperitoneally with 5 X 10(6) P. brasiliensis yeast cells, and mortality was scored daily. Analysis of susceptible and resistant parental strains and of F1, F2, and backcross mice showed that the resistance to P. brasiliensis seems to be controlled genetically by a single dominant gene, which we designated the Pbr locus. The mean survival times of susceptible F2 and backcross hybrids were very similar to that of the susceptible parent. Examination of the pathological changes observed in parental and F1 mice, 6 months after infection, showed that F1 offspring presented a similar number and distribution of lesions to those of the resistant strains. The Pbr gene is not linked to H-2, Hc, and albino genes. Furthermore, resistance to paracoccidioidomycosis is controlled by an autosomal gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.