ArticleBreast cancer research and treatment2022
Early postoperative psychological distress as a mediator of subsequent persistent postsurgical pain outcomes among younger breast cancer patients.
Article in Breast cancer research and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Genetic Variants with Postsurgical Pain: A Systematic Review and Meta-analyses.Anesthesiology · 2023Pooled it
- A study on the effect of clinical intervention of evidence-based nursing measures on complications in patients after breast-conserving surgery.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Trial
- Early post-operative changes in quality of life and psychological symptoms after breast cancer surgery: the role of perceived pain, upper limb disability, and disease acceptance.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Two-part Statistical Model for Identifying Baseline Predictors of Chronic Postsurgical Pain.Anesthesiology · 2026Article
- Age-related differences in psychological distress and persistent postsurgical pain after surgery for management of non-invasive breast lesions.Breast cancer research and treatment · 2026Article
- Article
- Development of a machine learning-based nomogram for predicting chronic postsurgical pain after uniportal video-assisted thoracoscopic surgery.Journal of thoracic disease · 2025Article
- Relationship between sleep disturbances and depressive symptoms in patients after general anesthesia: A retrospective case-control study.World journal of psychiatry · 2025Article
- Long-Term Analysis of Suicide Incidence Among Patients with Lung Cancer: A Population-Based Longitudinal Study.Journal of clinical medicine · 2025Article
- Article
- Psychosocial wellbeing of patients with breast cancer following surgical treatment in Northern Nigeria.BMC psychiatry · 2025Article
- The relationship among body image, psychological distress, and quality of life in young breast cancer patients: a cross-sectional study.Frontiers in psychology · 2024Article
- Care for breast cancer survivors in Asian countries: A review of sexual dysfunction.Women's health (London, England)Review
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Authors and funding
7 authors.
Funding
Abstract
purposeYounger age is a risk factor for worse pain outcomes following breast cancer surgery, yet little is known about how younger women's psychological state may contribute to their pain experience. Using prospectively collected longitudinal data from a surgical cohort, we examined whether early postoperative psychological distress at 2 weeks mediated the association between younger age and subsequent worse pain-related functioning 3 months after surgery.
methodsPatients (N = 159) were recruited before breast cancer surgery into this longitudinal cohort study. Age at time of surgery, psychological distress (anxiety, depression, and sleep disturbance) assessed 2 weeks postoperatively, and impact of surgical pain on cognitive/emotional functioning and physical functioning assessed 3 months postoperatively were used for analysis.
resultsYounger age was associated with greater depression, anxiety, and sleep disturbance 2 weeks postoperatively. Younger age was also associated with greater ratings of pain impacting cognitive/emotional functioning and physical functioning 3 months postoperatively. The association between younger age and worse cognitive/emotional impact of pain was mediated by greater anxiety and sleep disturbance. Similarly, the association between younger age and worse physical impact of pain was mediated by greater sleep disturbance.
conclusionThe degree of anxiety and sleep disturbance that occur early after breast surgery may contribute to greater chronic pain-related functional disability among younger patients. Anxiety and sleep disturbance are modifiable with behavioral interventions, making them potential perioperative targets to improve long-term outcomes in young breast cancer survivors.
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