ArticleDiabetologia2022
Associations of combined healthy lifestyles with cancer morbidity and mortality among individuals with diabetes: results from five cohort studies in the USA, the UK and China.
Article in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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26 citing papers in PubMed, 49 citations in OpenAlex.
- Cardiovascular-Kidney-Metabolic Syndrome, Healthy Lifestyles, and Risk of Cancer Incidence and Mortality: A Prospective Cohort Study.International journal of cancer · 2026Article
- Article
- A healthy lifestyle pattern and mortality risk in patients of type 2 diabetes mellitus: a prospective cohort study in China.Journal of biomedical research · 2025Article
- Prognostic and predictive effects of new steatotic liver disease nomenclatures: a large population-based study.MedComm · 2025Article
- Association between combined healthy lifestyles and infertility: a cross-sectional study in US reproductive-aged women.BMC public health · 2025Article
- The hidden impact: social isolation and inflammation's role in pancreatic cancer risk among those with diabetes.BMC cancer · 2025Article
- Combined healthy lifestyles and overactive bladder: a cross-sectional study of NHANES 2007-2020.Frontiers in nutrition · 2025Article
- Adherence to a healthy lifestyle in association with female infertility risk: the mediating role of uric acid.Frontiers in nutrition · 2025Article
- Effects of SGLT2 inhibitors and GLP-1 receptor agonists on glycemic variability, islet cell function, and insulin resistance in patients with type 2 diabetes mellitus and renal cell carcinoma.American journal of cancer research · 2025Article
- Body shape phenotype, TYG trajectory and the risk of digestive system cancers.Frontiers in nutrition · 2025Article
- Impact of modifiable healthy lifestyles on mortality in Chinese older adults.Scientific reports · 2024Article
- Healthy lifestyle associated with dynamic progression of type 2 diabetes: A multi-state analysis of a prospective cohort.Journal of global health · 2024Article
- Cardiovascular health and cancer mortality: evidence from US NHANES and UK Biobank cohort studies.BMC medicine · 2024Article
- The correlation between healthy lifestyle habits and all-cause and cardiovascular mortality in Guangxi.BMC public health · 2024Article
- Article
- Health impacts of lifestyle and ambient air pollution patterns on all-cause mortality: a UK Biobank cohort study.BMC public health · 2024Article
- Association of lifestyles and multimorbidity with mortality among individuals aged 60 years or older: Two prospective cohort studies.SSM - population health · 2024Article
- Association of Life's Essential 8 with all-cause mortality and risk of cancer: a prospective cohort study.BMC public health · 2024Article
- Diabetes-related risk factors and survival among individuals with type 2 diabetes and breast, lung, colorectal, or prostate cancer.Scientific reports · 2024Article
- Type 1 and type 2 diabetes mortality burden: Predictions for 2030 based on Bayesian age-period-cohort analysis of China and global mortality burden from 1990 to 2019.Journal of diabetes investigation · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 6 institutions in 2 countries.
Funding
Abstract
aims/hypothesisCancer has contributed to an increasing proportion of diabetes-related deaths, while lifestyle management is the cornerstone of both diabetes care and cancer prevention. We aimed to evaluate the associations of combined healthy lifestyles with total and site-specific cancer risks among individuals with diabetes.
methodsWe included 92,239 individuals with diabetes but without cancer at baseline from five population-based cohorts in the USA (National Health and Nutrition Examination Survey and National Institutes of Health [NIH]-AARP Diet and Health Study), the UK (UK Biobank study) and China (Dongfeng-Tongji cohort and Kailuan study). Healthy lifestyle scores (range 0-5) were constructed based on current nonsmoking, low-to-moderate alcohol drinking, adequate physical activity, healthy diet and optimal bodyweight. Cox regressions were used to calculate HRs for cancer morbidity and mortality, adjusting for sociodemographic, medical and diabetes-related factors.
resultsDuring 376,354 person-years of follow-up from UK Biobank and the two Chinese cohorts, 3229 incident cancer cases were documented, and 6682 cancer deaths were documented during 1,089,987 person-years of follow-up in the five cohorts. The pooled multivariable-adjusted HRs (95% CIs) comparing participants with 4-5 vs 0-1 healthy lifestyle factors were 0.73 (0.61, 0.88) for incident cancer and 0.55 (0.46, 0.67) for cancer mortality, and ranged between 0.41 and 0.63 for oesophagus, lung, liver, colorectum, breast and kidney cancers. Findings remained consistent across different cohorts and subgroups. CONCLUSIONS/
interpretationThis international cohort study found that adherence to combined healthy lifestyles was associated with lower risks of total cancer morbidity and mortality as well as several subtypes (oesophagus, lung, liver, colorectum, breast and kidney cancers) among individuals with diabetes.
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