ArticleJournal of the American Geriatrics Society2023
It's all about cognitive trajectory: Accuracy of the cognitive charts-MoCA in normal aging, MCI, and dementia.
Article in Journal of the American Geriatrics Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Study protocol for FAXAge: a randomized, controlled clinical trial of fasting and exercise to slow aging in humans.GeroScience · 2026Trial
- Safety and efficacy of low-dose esketamine in laparoscopic cholecystectomy: a prospective, double-blind randomized controlled trial.BMC anesthesiology · 2024Trial
- Early Alzheimer´s disease blood biomarkers are associated with a higher risk for postoperative long-term cognitive decline: Insights from the FINDERI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- NSAID use is associated with lower dementia and Alzheimer's disease prevalence and slower cognitive decline: A retrospective longitudinal analysis of the NACC cohort.medRxiv : the preprint server for health sciences · 2026Article
- Lipidomic signatures associated with cognitive impairment in type 1 diabetes mellitus: a pilot study integrating clinical serum and mouse hippocampus.Journal of translational medicine · 2026Article
- Virtual reality-based cognitive assessment tools for mild cognitive impairment screening: comparison with traditional paper-and-pencil-based cognitive assessment tools.Innovation in aging · 2026Article
- Enhanced diagnostic interpretation of the MoCA using machine learning.Frontiers in neuroscience · 2026Article
- Cortical connectivity is associated with cognition across time in Parkinson's disease.Neuroimage. Reports · 2025Article
- An innovative health systems approach to support early detection of cognitive impairment in primary care - the brain health navigator.BMC primary care · 2025Article
- Psychometric Reliability, Validity, and Generalizability of MoCA in American Indian Adults: The Strong Heart Study.Assessment · 2025Article
- Cortical Surface Spatial Analysis Reveals Altered Brain Functional Network Topology in T2DM With Mild Cognitive Impairment.Brain and behavior · 2025Article
- Joint ensemble learning-based risk prediction of Alzheimer's disease among mild cognitive impairment patients.The journal of prevention of Alzheimer's disease · 2025Article
- Expanding the Applicability of Cognitive Charts to the Entire Age Span.Brain sciences · 2025Article
- Amygdala Nuclei Atrophy in Cognitive Impairment and Dementia: Insights from High-Resolution Magnetic Resonance Imaging.Medicina (Kaunas, Lithuania) · 2025Article
- VR Cognitive-based Intervention for Enhancing Cognitive Functions and Well-being in Older Adults with Mild Cognitive Impairment: Behavioral and EEG Evidence.Psychosocial intervention · 2025Article
- Exploring the link between tooth loss, cognitive function, and brain wellness in the context of healthy aging.Journal of periodontal research · 2024Article
- Montreal cognitive assessment as a cognitive outcome measure in progressive supranuclear palsy.Frontiers in neurology · 2024Article
- Whole Brain and Corpus Callosum Fractional Anisotropy Differences in Patients with Cognitive Impairment.Diagnostics (Basel, Switzerland) · 2023Article
- Predicting Progression from Normal to MCI and from MCI to AD Using Clinical Variables in the National Alzheimer's Coordinating Center Uniform Data Set Version 3: Application of Machine Learning Models and a Probability Calculator.The journal of prevention of Alzheimer's disease · 2023Article
- It's all about cognitive trajectory: Accuracy of the cognitive charts-MoCA in normal aging, MCI, and dementia.Journal of the American Geriatrics Society · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe Montreal Cognitive Assessment (MoCA) is an established cognitive screening tool in older adults. It remains unclear, however, how to interpret its scores over time and distinguish age-associated cognitive decline (AACD) from early neurodegeneration. We aimed to create cognitive charts using the MoCA for longitudinal evaluation of AACD in clinical practice.
methodsWe analyzed data from the National Alzheimer's Coordinating Center (9684 participants aged 60 years or older) who completed the MoCA at baseline. We developed a linear regression model for the MoCA score as a function of age and education. Based on this model, we generated the Cognitive Charts-MoCA designed to optimize accuracy for distinguishing participants with MCI and dementia from healthy controls. We validated our model using two separate data sets.
resultsFor longitudinal evaluation of the Cognitive Charts-MoCA, sensitivity (SE) was 89%, 95% confidence interval (CI): [86%, 92%] and specificity (SP) 79%, 95% CI: [77%, 81%], hence showing better performance than fixed cutoffs of MoCA (SE 82%, 95% CI: [79%, 85%], SP 68%, 95% CI: [67%, 70%]). For current cognitive status or baseline measurement, the Cognitive Charts-MoCA had a SE of 81%, 95% CI: [79%, 82%], SP of 84%, 95% CI: [83%, 85%] in distinguishing healthy controls from mild cognitive impairment or dementia. Results in two additional validation samples were comparable.
conclusionsThe Cognitive Charts-MoCA showed high validity and diagnostic accuracy for determining whether older individuals show abnormal performance on serial MoCAs. This innovative model allows longitudinal cognitive evaluation and enables prompt initiation of investigation and treatment when appropriate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.