ArticleJournal of the American College of Surgeons2022
Long-Term, Prospective, Multicenter Study of Poly-4-Hydroxybutyrate Mesh (Phasix Mesh) for Hernia Repair in Cohort at Risk for Complication: 60-Month Follow-Up.
Article in Journal of the American College of Surgeons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Contemporary management of the open abdomen: standards, challenges, and future directions.Langenbeck's archives of surgery · 2026Pooled it
- Ventral hernia is a chronic disease: a systematic review of long-term outcomes beyond 5 years.Hernia : the journal of hernias and abdominal wall surgery · 2025Pooled it
- The use of poly-4-hydroxybutyrate (P4HB, Phasix™) mesh in ventral hernia repair: a systematic review and meta-analysis.Hernia : the journal of hernias and abdominal wall surgery · 2024Pooled it
- Comparison of mesh infection management following ventral hernia repair with poly-4-hydroxybutyrate, synthetic, and biologic mesh: a retrospective review.Surgical endoscopy · 2026Article
- Comparative outcomes of bioabsorbable poly-4-hydroxybutyrate versus synthetic mesh in ventral hernia repair: A propensity-matched cohort study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Beyond acronyms: a domain-based structural analysis of abdominal wall hernia repair techniques in the contemporary literature.Surgical endoscopy · 2026Article
- Long-Term Outcomes After Slowly Resorbable P4HB Mesh Implantation: A Multicenter Analysis From European Registry.World journal of surgery · 2026Article
- Staged approach to chronic mesh infection following hernia repair: a single-center experience.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Patient-engaged preoperative optimization for a complex incisional hernia: a case report.Frontiers in surgery · 2026Article
- Health-related quality of life outcomes of bioabsorbable Phasix Mesh versus permanent synthetic mesh following open ventral hernia repair: a systematic literature review and narrative synthesis.Journal of abdominal wall surgery : JAWS · 2026Review
- Editorial: Biosynthetic resorbable meshes: a New frontier in abdominal wall hernia repair.Frontiers in surgery · 2026Article
- How Reproducible Are Abdominal Wall Surgical Techniques? A Methodological Assessment of Technical Reporting in the Contemporary Literature.Journal of abdominal wall surgery : JAWS · 2026Article
- Evaluating the Role of PhasixST™ Mesh in Laparoscopic Repair of Large Hiatal Hernias: Surgical Technique and Comprehensive Review of the Literature.Journal of clinical medicine · 2025Review
- Bio-resorbable poly-4-hydroxybutyrate (P4HB) mesh for abdominal wall reconstruction is effective in high-risk patients and contaminated abdomen.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Clinical outcomes of oncologic hernia repair using Poly-4-Hydroxybutyrate (P4HB) mesh.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Evaluating P4HB mesh in oncologic hernia repair: promise and perspective.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Review
- Long-term outcomes of open midline ventral hernia repair using a narrow well-fixed retrorectus polypropylene mesh.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Robotic transversus abdominis release (TAR) for ventral hernia repairs is associated with low surgical site occurrence rates and length of stay despite increasing modifiable comorbidities.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Medium term (> 12 months) outcomes after laparoscopic hiatal hernia repair without conventional fundoplication using PH4B-mesh implant (Phasix™) in 176 reflux patients: experience and technique.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
Corrections and comments
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Authors and funding
21 authors at 15 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term resorbable mesh represents a promising technology for ventral and incisional hernia repair (VIHR). This study evaluates poly-4-hydroxybutyrate mesh (P4HB; Phasix Mesh) among comorbid patients with CDC class I wounds. STUDY
designThis prospective, multi-institutional study evaluated P4HB VIHR in comorbid patients with CDC class I wounds. Primary outcomes included hernia recurrence and surgical site infection. Secondary outcomes included pain, device-related adverse events, quality of life, reoperation, procedure time, and length of stay. Evaluations were scheduled at 1, 3, 6, 12, 18, 24, 30, 36, and 60 months. A time-to-event analysis (Kaplan-Meier) was performed for primary outcomes; secondary outcomes were reported as descriptive statistics.
resultsA total of 121 patients (46 male, 75 female) 54.7 ± 12.0 years old with a BMI of 32.2 ± 4.5 kg/m 2 underwent VIHR with P4HB Mesh (mean ± SD). Fifty-four patients (44.6%) completed the 60-month follow-up. Primary outcomes (Kaplan-Meier estimates at 60 months) included recurrence (22.0 ± 4.5%; 95% CI 11.7% to 29.4%) and surgical site infection (10.1 ± 2.8%; 95% CI 3.3 to 14.0). Secondary outcomes included seroma requiring intervention (n = 9), procedure time (167.9 ± 82.5 minutes), length of stay (5.3 ± 5.3 days), reoperation (18 of 121, 14.9%), visual analogue scale-pain (change from baseline -3.16 ± 3.35 cm at 60 months; n = 52), and Carolinas Comfort Total Score (change from baseline -24.3 ± 21.4 at 60 months; n = 52).
conclusionsFive-year outcomes after VIHR with P4HB mesh were associated with infrequent complications and durable hernia repair outcomes. This study provides a framework for anticipated long-term hernia repair outcomes when using P4HB mesh.
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