Evidence map›Paper›PMID 36102277›Full record

ArticleJournal of the American Heart Association2022

Race, Interleukin-6,

Ian R Barrows, Matt Devalaraja, Rahul Kakkar, Jing Chen, Jayanta Gupta, Sylvia E Rosas, Santosh Saraf, Jiang He, Alan Go, Dominic S Raj and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

  1. Cardiovascular Disease in CKD: Ethnic and Regional Differences in Risk and Phenotype.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  2. Review
  3. Addressing Unmet Needs in the Management of Chronic Kidney Disease.International journal of general medicine · 2026
    Review
  4. IL-6 and Cardiovascular Risk: A Narrative Review.Current atherosclerosis reports · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Mechanisms controlling cellular and systemic iron homeostasis.Nature reviews. Molecular cell biology · 2024
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Ian R BarrowsDivision of Cardiology George Washington University School of Medicine Washington DC.
Matt DevalarajaResearch & Development Corvidia Therapeutics Waltham MA.ORCID 0000-0003-1531-0303
Rahul KakkarResearch & Development Corvidia Therapeutics Waltham MA.ORCID 0000-0003-1273-0441
Jing ChenSection of Nephrology and Hypertension, Department of Medicine Tulane University School of Medicine New Orleans LA.ORCID 0000-0002-9035-9126
Jayanta GuptaDepartment of Health Sciences, Marieb College of Health & Human Services Florida Gulf Coast University Fort Myers FL.ORCID 0000-0003-0332-6623
Sylvia E RosasDepartment of Medicine Joslin Diabetes Center, Harvard Medical School Boston MA.ORCID 0000-0002-9903-4002
Santosh SarafDivision of Hematology/Oncology, Department of Medicine University of Illinois at Chicago IL.ORCID 0000-0002-8584-4194
Jiang HeDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA.ORCID 0000-0002-8286-9652
Alan GoDivision of Research Kaiser Permanente Northern California Oakland CA.ORCID 0000-0001-9109-0811
Dominic S RajDivision of Kidney Diseases and Hypertension, Department of Medicine The George Washington University School of Medicine and Health Sciences Washington DC.
Richard L AmdurDepartment of Surgery The George Washington University School of Medicine and Health Sciences Washington DC.ORCID 0000-0002-4900-653X
CRIC Study Investigators *
George Washington University · USTulane University · USFlorida Gulf Coast University · USJoslin Diabetes Center · USKaiser Permanente · USUniversity of Illinois Chicago · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Scientific and Data Coordinating Center(SDCC) for the P*U01DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI FELDMAN, HAROLD I · 2001 to 2017
$50.1M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Ning Liu · 2016 to 2026
$25.3M
Continuation of the Coordinating Center for the Chronic Renal Insufficiency Cohort (CRIC) StudyU24DK060990 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Amanda Hyre Anderson, Laura M Dember · 2018 to 2026
$21.5M
Study of the Care and Outcomes of REnal InsufficiencyU01DK060902 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI GO, ALAN S · 2001 to 2025
$19.5M
Limited Competition for the Continuation of the Chronic Renal Insufficiency CohorU01DK061021 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI RAHMAN, MAHBOOB · 2001 to 2025
$17.3M
Prospective Renal Insufficiency Cohort Evaluation:PRICEU01DK060984 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI COHEN, DEBBIE L · 2001 to 2025
$17.0M
NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR002240NCATS NIH HHS UL1 TR002548NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR029879NHLBI NIH HHS R01 HL153161NIDDK NIH HHS R01 DK073665NIDDK NIH HHS R01 DK119199NIDDK NIH HHS R01 DK125256NIDDK NIH HHS U01 DK060902NIDDK NIH HHS U01 DK060963NIDDK NIH HHS U01 DK060980NIDDK NIH HHS U01 DK060984NIDDK NIH HHS U01 DK060990NIDDK NIH HHS U01 DK061021NIDDK NIH HHS U01 DK061022NIDDK NIH HHS U01 DK061028NIDDK NIH HHS U01 DK099914NIDDK NIH HHS U01 DK099924NIDDK NIH HHS U24 DK060990NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

Background Differences in death rate and cardiovascular disease (CVD) between Black and White patients with chronic kidney disease is attributed to sociocultural factors, comorbidities, genetics, and inflammation. Methods and Results We examined the interaction of race, plasma IL-6 (interleukin-6), and

Indexed as

Cardiovascular DiseasesInterleukin-6Membrane ProteinsRenal Insufficiency, ChronicSerine EndopeptidasesAlbuminsCohort StudiesCreatinineGenotypeHumansAlbuminsCreatinineInterleukin-6Membrane ProteinsSerine EndopeptidasesTMPRSS6 protein, humananemiacytokinesgeneticsinflammationmortalityprogression of chronic kidney disease

Identifiers

PMID36102277
PMCPMC9683639
OpenAlexW4295569562

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.