Evidence map›Paper›PMID 36102228›Full record

ArticleJournal of the American Heart Association2022

Impact of Socioeconomic Status on Mortality and Readmission in Patients With Heart Failure With Reduced Ejection Fraction: The ARIC Study.

Lena Mathews, Ning Ding, Yejin Mok, Jung-Im Shin, Deidra C Crews, Wayne D Rosamond, Anna-Kucharska Newton, Patricia P Chang, Chiadi E Ndumele, Josef Coresh and 1 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Well-Known and Novel Behavioural Risk Factors for Heart Failure.Journal of cardiovascular development and disease · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Impact of Social Determinants of Health on Cardiovascular Disease.Journal of the American Heart Association · 2025
    Review
  13. Increasing Readmissions of HFpEF and the Burden They Cause.International journal of heart failure · 2025
    Article
  14. Article
  15. Comorbidities and determinants of health on heart failure guideline-directed medical therapy adherence: All of us.International journal of cardiology. Cardiovascular risk and prevention · 2024
    Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lena MathewsWelch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology Johns Hopkins University Baltimore MD.ORCID 0000-0003-3780-7572
Ning DingWelch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology Johns Hopkins University Baltimore MD.ORCID 0000-0002-3023-8613
Yejin MokWelch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology Johns Hopkins University Baltimore MD.ORCID 0000-0002-8511-604X
Jung-Im ShinWelch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology Johns Hopkins University Baltimore MD.ORCID 0000-0003-0374-6927
Deidra C CrewsWelch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology Johns Hopkins University Baltimore MD.ORCID 0000-0003-3425-5776
Wayne D RosamondGillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill NC.ORCID 0000-0001-5271-074X
Anna-Kucharska NewtonGillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill NC.
Patricia P ChangGillings School of Global Public Health University of North Carolina at Chapel Hill Chapel Hill NC.
Chiadi E NdumeleWelch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology Johns Hopkins University Baltimore MD.ORCID 0000-0002-1603-282X
Josef CoreshWelch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology Johns Hopkins University Baltimore MD.ORCID 0000-0002-4598-0669
Kunihiro MatsushitaWelch Center for Prevention, Epidemiology, and Clinical Research, Department of Epidemiology Johns Hopkins University Baltimore MD.ORCID 0000-0002-7179-718X

Funding

The Comparative Effectiveness and Safety of Second-line Therapy in Patients with Type 2 DiabetesK01DK121825 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SHIN, JUNG-IM · 2019 to 2022
$615k
NHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005INIDDK NIH HHS K01 DK121825
6 · The paper itself

Abstract

Background Low socioeconomic status (SES) is associated with a higher risk of heart failure (HF). The contribution of individual and neighborhood SES to the prognosis and quality of care for HF with reduced ejection fraction is not clear yet has important implications. Methods and Results We examined 728 participants of the ARIC (Atherosclerosis Risk in Communities) study (mean age, 78.2 years; 34% Black participants; 46% women) hospitalized with HF with reduced ejection fraction (ejection fraction <50%) between 2005 and 2018. We assessed associations between education, income, and area deprivation index with mortality and HF readmission using multivariable Cox models. We also evaluated the use of guideline-directed medical therapy (optimal: ≥3 of ß-blockers, mineralocorticoid receptor antagonist, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers; acceptable: at least 2) at discharge. During a median follow-up of 3.2 years, 58.7% were readmitted with HF, and 74.0% died. Low income was associated with higher mortality (hazard ratio [HR], 1.52 [95% CI, 1.14-2.04]) and readmission (HR, 1.45 [95% CI, 1.04-2.03]). Similarly, low education was associated with mortality (HR, 1.27 [95% CI, 1.01-1.59]) and readmission (HR, 1.62 [95% CI, 1.24-2.12]). The highest versus lowest area deprivation index quartile was associated with readmission (HR, 1.69 [95% CI, 1.11-2.58]) but not necessarily with mortality. The prevalence of optimal guideline-directed medical therapy and acceptable guideline-directed medical therapy was 5.5% and 54.4%, respectively, but did not significantly differ by SES. Conclusions Among patients hospitalized with HF with reduced ejection fraction, low SES was independently associated with mortality and HF readmission. A targeted secondary prevention approach that focuses intensive efforts on patients with low SES will be necessary to improve outcomes of those with HF with reduced ejection fraction.

Indexed as

Heart FailureVentricular Dysfunction, LeftAgedAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsFemaleHumansMaleMineralocorticoid Receptor AntagonistsPatient ReadmissionSocial ClassAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsMineralocorticoid Receptor Antagonistsguideline‐directed medication therapyheart failure with reduced ejection fractionmortalityoutcomesreadmissionsocioeconomic status

Identifiers

PMID36102228
PMCPMC9683665

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.