Evidence map›Paper›PMID 36102221›Full record

ArticleJournal of the American Heart Association2022

Outcomes Following Acute Coronary Syndrome in Patients With and Without Rheumatic Immune-Mediated Inflammatory Diseases.

Heba Wassif, Marwan Saad, Rajul Desai, Rula A Hajj-Ali, Venu Menon, Pulkit Chaudhury, Michael Nakhla, Rishi Puri, Sameer Prasada, Grant W Reed and 4 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Acute Coronary Syndrome and Rheumatic Disease.Journal of clinical medicine · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Heba WassifHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.
Marwan SaadLifespan Cardiovascular Institute Providence RI.ORCID 0000-0002-2280-8030
Rajul DesaiHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.
Rula A Hajj-AliDepartment of Rheumatic and Immunologic Disease Cleveland Clinic Cleveland OH.
Venu MenonHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.ORCID 0000-0003-4410-2677
Pulkit ChaudhuryHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.ORCID 0000-0002-8210-8394
Michael NakhlaHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.ORCID 0000-0002-8016-9679
Rishi PuriHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.
Sameer PrasadaHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.
Grant W ReedHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.ORCID 0000-0001-8234-3135
Khaled ZiadaHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.
Samir KapadiaHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.ORCID 0000-0002-0026-3391
Milind DesaiHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.ORCID 0000-0003-0010-9797
Amgad MentiasHeart, Vascular and Thoracic Institute Cleveland Clinic Cleveland OH.ORCID 0000-0001-6555-2517

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Rheumatic immune mediated inflammatory diseases (IMIDs) are associated with high risk of acute coronary syndrome. The long-term prognosis of acute coronary syndrome in patients with rheumatic IMIDs is not well studied. Methods and Results We identified Medicare beneficiaries admitted with a primary diagnosis of myocardial infarction (MI) from 2014 to 2019. Outcomes of patients with MI and concomitant rheumatic IMIDs including systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, dermatomyositis, or psoriasis were compared with propensity matched control patients without rheumatic IMIDs. One-to-three propensity-score matching was done for exact age, sex, race, ST-segment-elevation MI, and non-ST-segment-elevation MI variables and greedy approach on other comorbidities. The study primary outcome was all-cause mortality. The study cohort included 1 654 862 patients with 3.6% prevalence of rheumatic IMIDs, the most common of which was rheumatoid arthritis, followed by systemic lupus erythematosus. Patients with rheumatic IMIDs were younger, more likely to be women, and more likely to present with non-ST-segment-elevation MI. Patients with rheumatic IMIDs were less likely to undergo coronary angiography, percutaneous coronary intervention or coronary artery bypass grafting. After propensity-score matching, at median follow up of 24 months (interquartile range 9-45), the risk of mortality (adjusted hazard ratio [HR], 1.15 [95% CI, 1.14-1.17]), heart failure (HR, 1.12 [95% CI 1.09-1.14]), recurrent MI (HR, 1.08 [95% CI 1.06-1.11]), and coronary reintervention (HR, 1.06 [95% CI, 1.01-1.13]) (

Indexed as

Acute Coronary SyndromeArthritis, RheumatoidHeart FailureLupus Erythematosus, SystemicMyocardial InfarctionNon-ST Elevated Myocardial InfarctionAgedFemaleHumansMaleMedicareTime FactorsUnited Statesimmune medicated inflammatory diseasesmyocardial infarctionrheumatoid arthritissystemic lupus

Identifiers

PMID36102221
PMCPMC9683641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.