ArticleVox sanguinis2022
Single-exon approach to non-invasive fetal RHD screening in early pregnancy: An update after 10 years' experience.
Article in Vox sanguinis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Routine use of a spike-in DNA in-process control for foetal RHD genotyping: Testing the real-world effectiveness of this 'canary'.Vox sanguinis · 2026Article
- Novel proof of concept assay for rapid, simplified non-invasive fetal RhD screening.Scientific reports · 2025Article
- Noninvasive fetal blood group antigen genotyping.Blood transfusion = Trasfusione del sangue · 2025Review
- Single-exon fetal RHD genotyping: a 31-month follow up in the obstetric population of Western Sweden.Blood transfusion = Trasfusione del sangue · 2024Article
- Evaluation of an automated platform for non-invasive single-exon fetal RHD genotyping early in pregnancy.Blood transfusion = Trasfusione del sangue · 2023Article
- FetalBiomedicines · 2023Article
- Validation of a non-invasive prenatal test for fetal RhD, C, c, E, K and FyScientific reports · 2023Article
- Terminating Routine Cord Blood RhD Typing of the Newborns to Guide Postnatal Anti-D Immunoglobulin Prophylaxis Based on the Results of Fetal RHD Genotyping.Fetal diagnosis and therapy · 2023Article
- Single-exon approach to non-invasive fetal RHD screening in early pregnancy: An update after 10 years' experience.Vox sanguinis · 2022Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesAnti-D prophylaxis, administered to RhD-negative women, has significantly reduced the incidence of RhD immunization. Non-invasive fetal RHD screening has been used in Stockholm for more than 10 years to identify women who will benefit from prophylaxis. The method is based on a single-exon approach and is used in early pregnancy. The aim of this study was to update the performance of the method. MATERIALS AND
methodsThe single exon assay from Devyser AB is a multiplex kit detecting both exon 4 of the RHD gene and the housekeeping gene GAPDH. Cell-free DNA was extracted from 1 ml of plasma from EDTA blood taken during early pregnancy, weeks 10-12. The genetic RHD results were compared with serological typing of newborns for a determination of sensitivity and specificity.
resultsIn total, 4337 pregnancies were included in the study; 44 samples (1%) were inconclusive either due to maternal RHD gene variants (n = 34) or technical reasons (n = 10). Of the remaining 4293 pregnancies, a total number of nine discrepant results were found. False positive results (n = 7) were mainly (n = 4) due to RHD gene variants in the child. False-negative results were found in two cases, of which one was caused by a technical error. None of the false-negative cases was due to RHD gene variants. Overall, the sensitivity of the method was 99.93% and specificity 99.56%.
conclusionThe single-exon assay used in this study is correlated with high sensitivity and specificity.
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