ArticlePsychiatric research and clinical practice2020
Psychometric Properties of the Concise Associated Symptom Tracking Scale and Validation of Clinical Utility in the EMBARC Study.
Article in Psychiatric research and clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Cross-Sectional Associations Among Symptoms of Pain, Irritability, and Depression and How These Symptoms Relate to Social Functioning and Quality of Life: Findings From the EMBARC and STRIDE Studies and the VitalSign6 Project.The Journal of clinical psychiatry · 2021Trial
- Association between irritability and suicidal ideation in three clinical trials of adults with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Improvements in irritability with sertraline versus placebo: Findings from the EMBARC study.Journal of affective disorders · 2020Trial
- Associations Between Sleep and Adolescent Mental Health Before and During the COVID-19 Pandemic in a Partial Hospitalization Program.JAACAP open · 2026Article
- ADHD in Youth With Major Depressive Disorder in the Texas Youth Depression and Suicide Research Network (TX-YDSRN): Clinical Correlates and Moderators.Journal of attention disorders · 2025Article
- Article
- Spotlight on Pimavanserin Tartrate and Its Therapeutic Potential in the Treatment of Major Depressive Disorder: The Evidence to Date.Drug design, development and therapy · 2021Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The authors aimed to evaluate psychometric properties of the Concise Associated Symptom Tracking (CAST) Scale and validate the clinical utility of measuring irritability by updating and replicating a previously published outcome calculator from the Combining Medications to Enhance Depression Outcomes (CO-MED) trial. Methods: Participants were 292 adults from the Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study who had completed the CAST scale at baseline. The scale's five-domain (irritability, anxiety, mania, insomnia, and panic) structure was evaluated with confirmatory factor analysis. Correlations with other clinical measures were used to confirm convergent and divergent validity. Logistic regression analyses from CO-MED were used to estimate individual outcomes in EMBARC. Results: Cronbach's alpha for the CAST scale was 0.78. Model fit for the five-domain structure was adequate (goodness of fit index=0.93, comparative fit index=0.92, root mean square error of approximation=0.06). Scores on irritability, anxiety, panic, insomnia, and mania were correlated with scores on the Anger Attack Questionnaire irritability item (r Conclusions: Measuring irritability may help predict clinical course. The CAST scale is a valid measure of depression-associated symptoms, including irritability.
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